373403 Sigma-AldrichInSolution™ Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem
The InSolution™ Hh/Gli Antagonist, GANT61, also referenced under CAS 500579-04-4, controls the biological activity of Hh/Gli. This small molecule/inhibitor is primarily used for Cell Signaling applications.
More>> The InSolution™ Hh/Gli Antagonist, GANT61, also referenced under CAS 500579-04-4, controls the biological activity of Hh/Gli. This small molecule/inhibitor is primarily used for Cell Signaling applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-((3-(2-(Dimethylamino)benzyl)-2-(4-pyridinyl)tetrahydro-1(2H)-pyrimidinyl)methyl)-N,N-dimethylaniline, 2,2ʹ-(2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene)bis(N,N-dimethylaniline), NSC 136476
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 500579-04-4 | C₂₇H₃₅N₅ |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 373403-2MG |
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Glass bottle | 2 mg |
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| Description | |
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| Overview | A cell-permeable hexahydropyrimidine compound that displays similar pharmacological property as, but is structurally disctinct from, GANT58 (Cat. No. 373400). While both compounds act as downstream Hedgehog (Hh) pathway-selective blockers and target Gli-mediated gene transactivation with similar potency (IC50 ~5 µM) in SAG-stimulated Shh-L2 cells, GANT61 does exhibit better in vivo antitumor efficacy, presumably due to its superior pharmacokinetics, and only GANT61, but not GANT58, is shown to inhibit Gli DNA binding in HEK293 cells. The solid form of this compound (Cat. No. 373401) is also available. |
| Catalogue Number | 373403 |
| Brand Family | Calbiochem® |
| Synonyms | 2-((3-(2-(Dimethylamino)benzyl)-2-(4-pyridinyl)tetrahydro-1(2H)-pyrimidinyl)methyl)-N,N-dimethylaniline, 2,2ʹ-(2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene)bis(N,N-dimethylaniline), NSC 136476 |
| References | |
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| References | Lauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455. |
| Product Information | |
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| CAS number | 500579-04-4 |
| Form | Liquid |
| Formulation | A 25 mM (2 mg/186 µL) solution of Hh/Gli Antagonist, GANT61 (Cat. No. 373401) in DMSO. |
| Hill Formula | C₂₇H₃₅N₅ |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Gli1 and Gli2 |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 373403-2MG | 04055977191134 |
Documentation
InSolution™ Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem SDS
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InSolution™ Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 373403 |
References
| Reference overview |
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| Lauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455. |
| Data Sheet | ||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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