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382172 Histone Deacetylase Inhibitor VI, HNHA - CAS 926908-04-5 - Calbiochem

Overview

Key Specifications Table

CAS #Empirical Formula
926908-04-5C₁₇H₂₁NO₂S

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382172-10MG
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      Description
      OverviewA cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity (IC50 = 100 nM). Shown to induce histone acetylation and p21 transcription with concomitent inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. Reported to be more potent than SAHA in inhibiting tumor growth in a murine xenograph model in vivo.
      Catalogue Number382172
      Brand Family Calbiochem®
      SynonymsN-Hydroxy-7-(2-naphthylthio)heptanomide
      References
      ReferencesKim, D.H., et al. 2007. Biochem. Biophys. Res. Commun. 356, 233.
      Product Information
      CAS number926908-04-5
      FormWhite solid
      Hill FormulaC₁₇H₂₁NO₂S
      Chemical formulaC₁₇H₂₁NO₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 22-24/25-36/37/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalog Number GTIN
      382172-10MG 04055977212785