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508226 InSolution™ Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: protein phosphatase-2A & -1
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508226
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
101932-71-2C₅₀H₈₁N₄O₁₅P

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5.08226.0001
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      Description
      Catalogue Number508226
      Brand Family Calbiochem®
      References
      ReferencesMurakami, N., et al. 1994. Neurosci. Lett. 176, 181.
      Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
      Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
      Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
      Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
      Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
      Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
      Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
      Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
      Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
      Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
      Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.
      Product Information
      CAS number101932-71-2
      FormLiquid
      FormulationA 100 µM (5 µg/50 µL) sterile-filtered solution of Calyculin A, Discodermia calyx (Cat. No. 208851) in DMSO.
      Hill FormulaC₅₀H₈₁N₄O₁₅P
      Chemical formulaC₅₀H₈₁N₄O₁₅P
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetprotein phosphatase-2A & -1
      Primary Target IC<sub>50</sub>0.5-1.0 and 2 nM for PP2A and PP1, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      5.08226.0001 04055977261776

      Documentation

      InSolution™ Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Murakami, N., et al. 1994. Neurosci. Lett. 176, 181.
      Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
      Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
      Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
      Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
      Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
      Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
      Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
      Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
      Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
      Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
      Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-December-2013 JSW
      DescriptionCell-permeable protein phosphatase 2A (PP2A) inhibitor (IC50 = 0.5-1.0 nM). Also inhibits protein phosphatase 1 (PP1; IC50 = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Recently, it has been used to study the regulation of Ca2+-activated K+ channels in smooth muscle and to correlate shape changes in fibroblasts with the degree of protein phosphorylation. Also known to prevent γ-radiation induced apoptosis in Burkitt's lymphoma cell line BM13674.
      FormLiquid
      FormulationA 100 µM (5 µg/50 µL) sterile-filtered solution of Calyculin A, Discodermia calyx (Cat. No. 208851) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number101932-71-2
      Chemical formulaC₅₀H₈₁N₄O₁₅P
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
      Toxicity Standard Handling
      ReferencesMurakami, N., et al. 1994. Neurosci. Lett. 176, 181.
      Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
      Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
      Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
      Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
      Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
      Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
      Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
      Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
      Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
      Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
      Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.