516481 Sigma-AldrichPepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem
Pepstatin A, Synthetic, CAS 26305-03-3, is a reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin.
More>> Pepstatin A, Synthetic, CAS 26305-03-3, is a reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
Recommended Products
Overview
| Replacement Information |
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Key Specifications Table
| CAS # | Empirical Formula |
|---|---|
| 26305-03-3 | C₃₄H₆₃N₅O₉ |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 516481-100MG |
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Plastic ampoule | 100 mg |
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| 516481-25MG |
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Plastic ampoule | 25 mg |
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| 516481-5MG |
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Plastic ampoule | 5 mg |
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| Description | |
|---|---|
| Overview | A reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cell lines. Also available as a 25 mM solution in DMSO (Cat. No. 508437). |
| Effective concentration: 1.0 µM. | |
| Catalogue Number | 516481 |
| Brand Family | Calbiochem® |
| Synonyms | Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid |
| Product Information | |
|---|---|
| CAS number | 26305-03-3 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₃₄H₆₃N₅O₉ |
| Chemical formula | C₃₄H₆₃N₅O₉ |
| Optical rotation | Optical rotation: -90.0 ± 5° (c = 0.5, MeOH, 20°C). |
| Reversible | Y |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
|---|---|
| Primary Target | cathepsin D |
| Primary Target IC<sub>50</sub> | EC50 = 1.0 µM in blocking apoptosis induced by CA-074 in PC12 cell lines |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | N |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS | |
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| RTECS | SC6155000 |
| Safety Information |
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| Product Usage Statements |
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| Packaging Information |
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| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 516481-100MG | 04055977198812 |
| 516481-25MG | 07790788055837 |
| 516481-5MG | 04055977198836 |
Documentation
Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem SDS
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Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 516481 |
References
| Reference overview |
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| Isahara, K., et al. 1999. Neuroscience 91, 233. Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204. Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233. Carraway, R.E., et al. 1991. Peptides 12, 107. Eid, M., et al. 1981. Biochem. J. 197, 465. Umezawa, H., et al. 1970. J. Antibiot. 23, 259. |
Technical Info
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| Protein Blotting Handbook: 6th Edition |