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524394 4α-Phorbol-12,13-didecanoate - CAS 27536-56-7 - Calbiochem

4α-Phorbol-12,13-didecanoate, CAS 27536-56-7, is a negative control for phorbol esters PDD (Cat. No. 524392) & PMA (Cat. No. 524400). Inactive on mouse skin as an inflammatory & tumorigenic agent.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4αPDD, PKC Activator I, Negative Control

Primary Target: A negative control for Phorbol-12,13-didecanoate (PDD) and Phorbol-12-myristate-13-acetate (PMA)
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524394
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
27536-56-7C₄₀H₆₄O₈

Pricing & Availability

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524394-1MG
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      524394-5MG
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          Description
          OverviewInactive on mouse skin as an inflammatory and tumor-promoting agent. Useful as a negative control for Phorbol-12,13-didecanoate (PDD; Cat. No. 524392) and Phorbol-12-myristate-13-acetate (PMA; Cat. No. 524400).
          Catalogue Number524394
          Brand Family Calbiochem®
          Synonyms4αPDD, PKC Activator I, Negative Control
          References
          ReferencesAkiguchi, I., et al. 1993. Endocrinology 138, 379.
          Clarke, B.L., et al. 1993. Endocrinology 132, 1168.
          Natarajan, V. and Garcia, J.G. 1993. J. Lab. Clin. Med. 121, 337.
          Slomiany, B.L., et al. 1992. J. Physiol. Pharmacol. 43, 223.
          Product Information
          CAS number27536-56-7
          ATP CompetitiveN
          FormSolid
          Hill FormulaC₄₀H₆₄O₈
          Chemical formulaC₄₀H₆₄O₈
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Application4α-Phorbol-12,13-didecanoate, CAS 27536-56-7, is a negative control for phorbol esters PDD (Cat. No. 524392) & PMA (Cat. No. 524400). Inactive on mouse skin as an inflammatory & tumorigenic agent.
          Biological Information
          Primary TargetA negative control for Phorbol-12,13-didecanoate (PDD) and Phorbol-12-myristate-13-acetate (PMA)
          Purity>99% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 26/27/28-36/37/38

          Very toxic by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-27-36/37/39-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Take off immediately all contaminated clothing.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalog Number GTIN
          524394-1MG 04055977271560
          524394-5MG 04055977271577

          Documentation

          4α-Phorbol-12,13-didecanoate - CAS 27536-56-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          4α-Phorbol-12,13-didecanoate - CAS 27536-56-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          524394

          References

          Reference overview
          Akiguchi, I., et al. 1993. Endocrinology 138, 379.
          Clarke, B.L., et al. 1993. Endocrinology 132, 1168.
          Natarajan, V. and Garcia, J.G. 1993. J. Lab. Clin. Med. 121, 337.
          Slomiany, B.L., et al. 1992. J. Physiol. Pharmacol. 43, 223.

          Brochure

          Title
          PKC Pathway Poster PDF ( 676 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-May-2008 RFH
          Synonyms4αPDD, PKC Activator I, Negative Control
          DescriptionReported to be inactive on mouse skin as an inflammatory and tumor-promoting agent. Used as a negative control for phorbol-12,13-didecanoate (PDD, Cat. No. 524392) and phorbol-12-myristate-13-acetate (PMA, Cat. No. 524400).
          FormSolid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number27536-56-7
          Chemical formulaC₄₀H₆₄O₈
          Structure formulaStructure formula
          Purity>99% by HPLC
          SolubilityDMSO or ethanol
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
          Toxicity Highly Toxic
          ReferencesAkiguchi, I., et al. 1993. Endocrinology 138, 379.
          Clarke, B.L., et al. 1993. Endocrinology 132, 1168.
          Natarajan, V. and Garcia, J.G. 1993. J. Lab. Clin. Med. 121, 337.
          Slomiany, B.L., et al. 1992. J. Physiol. Pharmacol. 43, 223.