Catalog No.	Product Name	Target/Action	Cell Type	Concentration of Inhibitor	Link to Publication
688000	Y-27632	p160 ROCK	Primary 0ligodendrocyte precursor cells (OPCs)	10 mM	Slit2 Regulates the Dispersal of Oligodendrocyte Precursor Cells via Fyn/RhoA Signaling
688000	Y-27632	p160 ROCK	Human mammary epithelial cells (HMECs), HMT3522, and MCF10A	5 mM	Coherent angular motion in the establishment of multicellular architecture of glandular tissues
474790	MG-132	Proteasome	293T	25 mM	Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1
474790	MG-132	Proteasome	PC12	20 mM	Sh3rf2/POSHER Protein Promotes Cell Survival by Ring-mediated Proteasomal Degradation of the c-Jun N-terminal Kinase Scaffold POSH (Plenty of SH3s) Protein
239804	Cyclopamine-KAAD	Hedgehog (Hh) signaling	Ptch-/-cells	1 mM	Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3β Regulates Its Stability and Localization in the Primary Cilium
239804	Cyclopamine-KAAD	Hedgehog (Hh) signaling	Lamprey embryos	100 mM	Involvement of Hedgehog and FGF signalling in the lamprey telencephalon: evolution of regionalization and dorsoventral patterning of the vertebrate forebrain
566660	Smoothened Agonist, SAG	Smo	Bichirs, Polypterus senegalus and P. ornatipinnis	200 nM	Full regeneration of the tribasal Polypterus fin
566660	Smoothened Agonist, SAG	Smo	Primary mouse embryonic fibroblasts (pMEFs)	100 nM	Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components
553210	Rapamycin	Mammalian target of rapamycin (mTOR)	MCF-10A cells	20 nM	Akt and ERK Control the Proliferative Response of Mammary Epithelial Cells to the Growth Factors IGF-1 and EGF Through the Cell Cycle Inhibitor p57Kip2
553210	Rapamycin	Mammalian target of rapamycin (mTOR)	HeLa cells	200 nM	The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
627610	Caspase Inhibitor I	Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells	BC-3 cells	100 mM	Cdk1 Inhibition Induces Mutually Inhibitory Apoptosis and Reactivation of Kaposi's Sarcoma-Associated Herpesvirus
627610	Caspase Inhibitor I	Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells	RPE-1 cells	50 mM	Caspase activity is not required for the mitotic checkpoint or mitotic slippage in human cells
440202	LY 294002	Phosphatidylinositol 3-kinase	HeLa cells	50 mM	Autophagic Clearance of Sin Nombre Hantavirus Glycoprotein Gn Promotes Virus Replication in Cells
440202	LY 294002	Phosphatidylinositol 3-kinase	FaDu pharynx carcinoma cells	15 mM	Heparanase Induces Signal Transducer and Activator of Transcription (STAT) Protein Phosphorylation, PRECLINICAL AND CLINICAL SIGNIFICANCE IN HEAD AND NECK CANCER
565789	γ-Secretase Inhibitor XX	γ-secretase	HEK293	100 nM	First and Second Generation γ-Secretase Modulators (GSMs) Modulate Amyloid-β (Aβ) Peptide Production through Different Mechanisms
565789	γ-Secretase Inhibitor XX	γ-secretase	Telomerase-immortalized human corneal-limbal (HCLE) and conjunctival (HCjE) epithelial cells	10 mM and 25 mM	Notch Signaling Modulates MUC16 Biosynthesis in an In Vitro Model of Human Corneal and Conjunctival Epithelial Cell Differentiation
551476	InSolution™ Q-VD-OPh, Non-O-methylated	Broad-spectrum caspase inhibitor	RPE-1 cells	50 mM	Caspase activity is not required for the mitotic checkpoint or mitotic slippage in human cells
551476	InSolution™ Q-VD-OPh, Non-O-methylated	Broad-spectrum caspase inhibitor	Raji cells	20 mM	Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies
559389	SB 203580	p38 MAPK	HUVEC	10 mM	Angiotensin II increases the permeability and PV-1 expression of endothelial cells
559389	SB 203580	p38 MAPK	NIH3T3	5 mM	Lipocalin-type Prostaglandin D2 Synthase Protein Regulates Glial Cell Migration and Morphology through Myristoylated Alanine-rich C-Kinase Substrate, PROSTAGLANDIN D2-INDEPENDENT EFFECTS
426100	Lactacystin, Synthetic	20S proteasome	BHK cells	2 mM and 10 mM	The Immune Response to a Vesicular Stomatitis Virus Vaccine Vector Is Independent of Particulate Antigen Secretion and Protein Turnover Rate
426100	Lactacystin, Synthetic	20S proteasome	Neonatal rat cardiomyocytes	10 mM	c-Cbl Ubiquitin Ligase Regulates Focal Adhesion Protein Turnover and Myofibril Degeneration Induced by Neutrophil Protease Cathepsin G
662005	U0126	MEK1 and MEK2	Packed RBCs	5 mM	Erythrocyte plasma membrane–bound ERK1/2 activation promotes ICAM-4–mediated sickle red cell adhesion to endothelium
662005	U0126	MEK1 and MEK2	Jurkat	10 mM	α2β1 Integrin Promotes Chemoresistance against Doxorubicin in Cancer Cells through Extracellular Signal-regulated Kinase (ERK)
553502	Rac1 Inhibitor	Rac1 GDP/GTP exchange activity	Kit 225 cells, an IL-2-dependent human T cell line	50 mM	Rac1 Protein Regulates Glycogen Phosphorylase Activation and Controls Interleukin (IL)-2-dependent T Cell Proliferation
553502	Rac1 Inhibitor	Rac1 GDP/GTP exchange activity	AsPC1	10 mM	Interplay between β1-Integrin and Rho Signaling Regulates Differential Scattering and Motility of Pancreatic Cancer Cells by Snail and Slug Proteins
420099	JAK Inhibitor I	Murine JAK1, JAK2, JAK3, Tyk2	Cerebellar granule neuron	1 mM	Signal Transducer and Activator of Transcription-5 Mediates Neuronal Apoptosis Induced by Inhibition of Rac GTPase Activity
420099	JAK Inhibitor I	Murine JAK1, JAK2, JAK3, Tyk2	Chronic lymphocytic leukemia (CLL) cells	0.15 mg/mL	Leflunomide Induces Apoptosis in Fludarabine-Resistant and Clinically Refractory CLL Cells
572630	SU5402	FGFR1	Mouse osteosarcoma AX cells	10 mg/mL	Fibroblast Growth Factor-2 Is an Important Factor that Maintains Cellular Immaturity and Contributes to Aggressiveness of Osteosarcoma
572630	SU5402	FGFR1	Xenopus spinal neurons	20 mM	Axonal filopodial asymmetry induced by synaptic target
420119	JNK Inhibitor II	JNK 1, JNK 2, JNK 3	HEK293	20 mM	Sh3rf2/POSHER Protein Promotes Cell Survival by Ring-mediated Proteasomal Degradation of the c-Jun N-terminal Kinase Scaffold POSH (Plenty of SH3s) Protein
420119	JNK Inhibitor II	JNK 1, JNK 2, JNK 3	T regulatory cell	25 mM	Loss of T Regulatory Cell Suppression following Signaling through Glucocorticoid-induced Tumor Necrosis Receptor (GITR) Is Dependent on c-Jun N-terminal Kinase Activation
513000	PD 98059	MAP kinase kinase (MEK)	MCF-7 cells	20 mM	Brain-Derived Neurotrophic Factor and Neurotrophin-4/5 Are Expressed in Breast Cancer and Can Be Targeted to Inhibit Tumor Cell Survival
513000	PD 98059	MAP kinase kinase (MEK)	oligodendrocyte	20 mM	Ghrelin Inhibits Hydrogen Peroxide-Induced Apoptotic Cell Death of Oligodendrocytes Via ERK and p38MAPK Signaling
529573	PP2	p56lck	HMVEC-L Culture	5 mM	TRAF6 Protein Couples Toll-like Receptor 4 Signaling to Src Family Kinase Activation and Opening of Paracellular Pathway in Human Lung Microvascular Endothelia
529573	PP2	p56lck	293 cells	1 mM	Identification of Estrogen Receptor β as a SUMO-1 Target Reveals a Novel Phosphorylated Sumoylation Motif and Regulation by Glycogen Synthase Kinase 3β
171260	AMPK Inhibitor, Compound C	AMPK	Human iPSC and hESC lines	2.5 mM	Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
171260	AMPK Inhibitor, Compound C	AMPK	Neonatal cardiomyocytes	1 mM	Adiponectin protects against doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK up-regulation
573102	STAT3 Inhibitor VI, S3I-201	Stat3	Human embryonic lung fibroblasts (HELF)	100 mM in vitro; 5 mg/kg for in vivo i.p. administration	Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesis
573102	STAT3 Inhibitor VI, S3I-201	Stat3	PC14PE6/AS2, A549, H1299, and H1650 cells	100 mM	Activation of the Signal Transducer and Activator of Transcription 3 Pathway Up-Regulates Estrogen Receptor-β Expression in Lung Adenocarcinoma Cells
565771	InSolution™ γ-Secretase Inhibitor X	γ-secretase (Aβtotal)	Neural stem cells	5 mM	C-terminal fragment of N-cadherin accelerates synapse destabilization by amyloid-β
565771	InSolution™ γ-Secretase Inhibitor X	γ-secretase (Aβtotal)	Neurons isolated from the hippocampi	5 mM	A Novel Role for γ-Secretase: Selective Regulation of Spontaneous Neurotransmitter Release from Hippocampal Neurons
586005	Thapsigargin	Endoplasmic reticular Ca2+ ATPase	SH-SY5Y cells	1 mM	Balancing Arc Synthesis, mRNA Decay, and Proteasomal Degradation
586005	Thapsigargin	Endoplasmic reticular Ca2+ ATPase	Peripheral blood lymphocyte	10 mM	NAD+ Levels Control Ca2+ Store Replenishment and Mitogen-induced Increase of Cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 Channel Gating in Human T Lymphocytes
208851	Calyculin A, Discodermia calyx	PP2A	Mouse embryonic fibroblast	5 nM	Involvement of Stress Kinase Mitogen-activated Protein Kinase Kinase 7 in Regulation of Mammalian Circadian Clock
208851	Calyculin A, Discodermia calyx	PP2A	HEK293E cells	20 nM	Intestinal Cell Kinase (ICK) Promotes Activation of mTOR Complex 1 (mTORC1) through Phosphorylation of Raptor Thr-908
569397	Staurosporine, Streptomyces sp.	PKA	COS-7 cells	1 mM	Cellular Pharmacology of Protein Kinase Mζ (PKMζ) Contrasts with Its in Vitro Profile
569397	Staurosporine, Streptomyces sp.	PKA	Splenic human T cells	10 ng/mL	Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation
481480	NF-κB SN50, Cell-Permeable Inhibitor Peptide	Translocation of the NF-κB active complex into the nucleus	RAW264.7 cells and 3T3-L1 preadipocytes	25 mg/ml	Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders
481480	NF-κB SN50, Cell-Permeable Inhibitor Peptide	Translocation of the NF-κB active complex into the nucleus	Immature CD11c+ DCs	50 μg/ml	Activation of NF-κB in CD8+ Dendritic Cells Ex Vivo by the γ134.5 Null Mutant Correlates with Immunity against Herpes Simplex Virus 1
495604	Okadaic Acid, Prorocentrum sp.	Protein phosphatase	Mitoplasts	0.5 mM	Glycogen synthase kinase 3β transfers cytoprotective signaling through connexin 43 onto mitochondrial ATP-sensitive K+ channels
495604	Okadaic Acid, Prorocentrum sp.	Protein phosphatase	HeLa cells	250 nM	Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia
361550	GSK-3 Inhibitor IX	GSK-3α/β	Huh-7 cells	2 mM	Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis
361550	GSK-3 Inhibitor IX	GSK-3α/β	BAECs	5 mM	Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition
118500	ATM Kinase Inhibitor	ATM Kinase	MCF7 cells	5 mM	Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction
118500	ATM Kinase Inhibitor	ATM Kinase	HCT116 cells	10 mM	Elevated Cyclin G2 Expression Intersects with DNA Damage Checkpoint Signaling and Is Required for a Potent G2/M Checkpoint Arrest Response to Doxorubicin
565790	γ-Secretase Inhibitor XXI, Compound E	γ-secretase and Notch processing Ab40 in CHO cells overexpressing wild type bAPP	Rec-1, SP-49, Mino	1mM	Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma
565790	γ-Secretase Inhibitor XXI, Compound E	γ-secretase and Notch processing Ab40 in CHO cells overexpressing wild type bAPP	Luminobasal cells	5 nM	Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch
491207	Novobiocin, Sodium Salt	Retrovirus RNA-dependent DNA polymerases	PC3 cells	100 nM	HSP90 and HSP70 Proteins Are Essential for Stabilization and Activation of WASF3 Metastasis-promoting Protein
491207	Novobiocin, Sodium Salt	Retrovirus RNA-dependent DNA polymerases	DL1 static cultures	0.5 mg/ml	Hydrogen Peroxide-Dependent DNA Release and Transfer of Antibiotic Resistance Genes in Streptococcus gordonii
438186	Lovastatin, Sodium Salt	3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase	Primary human skin fibroblasts	1, 4, 10, or 20 μM	Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect
438186	Lovastatin, Sodium Salt	3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase	T-ALL cells and T-lymphoblasts	1 μM	Statins inhibit T-acute lymphoblastic leukemia cell adhesion and migration through Rap1b
217699	Cdk1 Inhibitor IV, RO-3306	Cdk1	HeLa cells	9 mM	Multisite Phosphorylation Disrupts Arginine-Glutamate Salt Bridge Networks Required for Binding of Cytoplasmic Linker-associated Protein 2 (CLASP2) to End-binding Protein 1 (EB1)
217699	Cdk1 Inhibitor IV, RO-3306	Cdk1	Liver tumor cells	9 mM	Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration
124018	Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2	Akt1, Akt2, Akt3	Epithelial ovarian cancer (EOC)	5 mM	Modulation of AKT activity is associated with reversible dormancy in ascites-derived epithelial ovarian cancer spheroids
124018	Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2	Akt1, Akt2, Akt3	B cells	2 mM	p110δ Phosphoinositide 3-Kinase Represses IgE Switch by Potentiating BCL6 Expression
189485	Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable	CaM Kinase-2	Neuronal culture	1 mM	Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses
189485	Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable	CaM Kinase-2	Hippocampal neurons	10 mM	CPEB4 Is a Cell Survival Protein Retained in the Nucleus upon Ischemia or Endoplasmic Reticulum Calcium Depletion
219007	Caspase Inhibitor VI	General caspase inhibitor	Neutrophils	10 and 100 μM	Human NK Cells Induce Neutrophil Apoptosis via an NKp46- and Fas-Dependent Mechanism
219007	Caspase Inhibitor VI	General caspase inhibitor	U-937 cells	100 mM	CPTH6, a Thiazole Derivative, Induces Histone Hypoacetylation and Apoptosis in Human Leukemia Cells
565788	β-Secretase Inhibitor IV	BACE-1 human	Primary cortical neurons	1 μm	BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate
565788	β-Secretase Inhibitor IV	BACE-1 human	Mouse embryonic fibroblasts (MEFs)	10 mM	Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein
572630	SU5402	FGFR1	Mouse osteosarcoma AX cells	10 μg/mL	Fibroblast Growth Factor-2 Is an Important Factor that Maintains Cellular Immaturity and Contributes to Aggressiveness of Osteosarcoma
572630	SU5402	FGFR1	Primary cultures of Xenopus spinal neurons	20 μM	Axonal filopodial asymmetry induced by synaptic target
565784	InSolution™ γ-Secretase Inhibitor IX	Aβtotal	Plasmacytoid DC	0.05 ng/mL	TLR-activated conventional DCs promote γ-secretase-mediated conditioning of plasmacytoid DCs
565784	InSolution™ γ-Secretase Inhibitor IX	Aβtotal	Differentiating chick retinal neurons	1 mM	Nerve Growth Factor-Induced Cell Cycle Reentry in Newborn Neurons Is Triggered by p38MAPK-Dependent E2F4 Phosphorylation
579002	Tamoxifen, 4-Hydroxy-, (Z)-	PKC	HEK293	2 µM/ml	The epigenetic control of E-box and Myc-dependent chromatin modifications regulate the licensing of lamin B2 origin during cell cycle
579002	Tamoxifen, 4-Hydroxy-, (Z)-	PKC	Anterior cerebral arterial smooth muscle cells	1 μM and 10 μM	Do TRPC-like currents and G protein-coupled receptors interact to facilitate myogenic tone development?
472804	S-Methyl-L-thiocitrulline, Dihydrochloride	Nos neuronal rat	Full-thickness segments of mouse colon	10 μM	Nitric oxide regulation of colonic epithelial ion transport: a novel role for enteric glia in the myenteric plexus
472804	S-Methyl-L-thiocitrulline, Dihydrochloride	Nos neuronal rat	Mouse ventricular myocytes	10 μM	Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptor S-nitrosylation
344930	Furin Inhibitor I	Viral glycoproteins	Vero cells	0, 1, 5, or 10 μM	Mutation of the F-Protein Cleavage Site of Avian Paramyxovirus Type 7 Results in Furin Cleavage, Fusion Promotion, and Increased Replication In Vitro but Not Increased Replication, Tissue Tropism, or Virulence in Chickens
344930	Furin Inhibitor I	Viral glycoproteins	Cos7 cells	50 μM	ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site
171261	InSolution™ AMPK Inhibitor, Compound C	AMPK	iPSCs	2.5 μM	Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
171261	InSolution™ AMPK Inhibitor, Compound C	AMPK	Neonatal cardiomyocytes	1 mM	Adiponectin protects against doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK up-regulation
239803	Cyclopamine, V. californicum	Hh signaling in Shh-light2 assay	Chronic lymphocytic leukemia (CLL) cells	5μM	Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL
239803	Cyclopamine, V. californicum	Hh signaling in Shh-light2 assay	Zebrafish embryos	0.25-50 μM	Repression of Hedgehog signalling is required for the acquisition of dorsolateral cell fates in the zebrafish otic vesicle
124012	Akt Inhibitor V, Triciribine	Akt1,Akt 2, Akt3	Caco-2 cells	1 mM	LPA stimulates intestinal DRA gene transcription via LPA2 receptor, PI3K/AKT, and c-Fos-dependent pathway
124012	Akt Inhibitor V, Triciribine	Akt1,Akt 2, Akt3	Intraperitoneally injected into mice	1 mg/kg	S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release
567021	Simvastatin, Sodium Salt	3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase	T-ALL cells and T-lymphoblasts	1 μM	Statins inhibit T-acute lymphoblastic leukemia cell adhesion and migration through Rap1b
567021	Simvastatin, Sodium Salt	3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase	Human colorectal cancer (CRC) cells	0.2 μM	Effect of Simvastatin on Cetuximab Resistance in Human Colorectal Cancer With KRAS Mutations
559398	InSolution™ SB 203580	P38MAPK	Rat aorta SMCs	5 μM	Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2-dependent and c-Jun-mediated mechanism
539624	PKCζ Pseudosubstrate Inhibitor, Myristoylated	Insulin-stimulated transport in intact adinocytes	BALB/c-derived macrophages	15 μM	Reciprocal Regulation of Protein Kinase C Isoforms Results in Differential Cellular Responsiveness
539624539624	PKCζ Pseudosubstrate Inhibitor, Myristoylated	Insulin-stimulated transport in intact adinocytes	Bilaterally injected into rats	10 or 30 nmol/side	Inhibition of PKMζ in Nucleus Accumbens Core Abolishes Long-Term Drug Reward Memory
328007	ERK Inhibitor II, FR180204	ERK1 and ERK2	MLO-Y4 cells	10 μM	Thiazolidinediones Induce Osteocyte Apoptosis by a G Protein-coupled Receptor 40-dependent Mechanism
328007	ERK Inhibitor II, FR180204	ERK1 and ERK2	Spleen DC	10 mM	MyD88-Dependent TLR1/2 Signals Educate Dendritic Cells with Gut-Specific Imprinting Properties
565770	γ-Secretase Inhibitor IX	Aβtotal	Differentiating chick retinal neurons (DCRNs)	1mM	Nerve Growth Factor-Induced Cell Cycle Reentry in Newborn Neurons Is Triggered by p38MAPK-Dependent E2F4 Phosphorylation
565770	γ-Secretase Inhibitor IX	Aβtotal	DS cortical neurons	10 mM	A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome
420116	JNK Inhibitor I, (L)-Form, Cell-Permeable	JNK	Primary BMVECs	10 μM	Dyad of CD40/CD40 Ligand Fosters Neuroinflammation at the Blood–Brain Barrier and Is Regulated via JNK Signaling: Implications for HIV-1 Encephalitis
124018	Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2	Akt1, Akt2, Akt3	Splenic B cells	2 μM	p110δ Phosphoinositide 3-Kinase Represses IgE Switch by Potentiating BCL6 Expression
124018	Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2	Akt1, Akt2, Akt3	HEK293 cells	5 mM	AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer
124005	Akt Inhibitor	Akt (PKB)	SH-SY5Y cells	5 mM	Hydrogen sulfide protects SH-SY5Y cells against 6-hydroxydopamine-induced endoplasmic reticulum stress
124005	Akt Inhibitor	Akt (PKB)	HT22 cells	1 mM	Insulin Promotes Neuronal Survival via the Alternatively Spliced Protein Kinase CδII Isoform
573097	STAT3 Inhibitor III, WP1066	STAT3 pathway inhibitor	Bone marrow cells	5 mM	Induction of Bv8 Expression by Granulocyte Colony-stimulating Factor in CD11b+Gr1+ Cells: KEY ROLE OF Stat3 SIGNALING
573097	STAT3 Inhibitor III, WP1066	STAT3 pathway inhibitor	IGROV-1 high-grade serous ovarian cancer cells and TOV21G clear-cell cancer cells	1 mM	A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment
422709	KN-92	Negative control, CaM kinase 2	Caco-2BBe/HA-NHE3 cells	30 mM	Calmodulin Kinase II Constitutively Binds, Phosphorylates, and Inhibits Brush Border Na+/H+ Exchanger 3 (NHE3) by a NHERF2 Protein-dependent Process
422709	KN-92	Negative control, CaM kinase 2	Cortical neurons	1 mM	Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Inhibition Induces Neurotoxicity via Dysregulation of Glutamate/Calcium Signaling and Hyperexcitability
422708	KN-93	CaM kinase II	Cortical neurons	1 mM	Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Inhibition Induces Neurotoxicity via Dysregulation of Glutamate/Calcium Signaling and Hyperexcitability
422708	KN-93	CaM kinase II	Caco-2BBe cells	30 μM	Calmodulin Kinase II Constitutively Binds, Phosphorylates, and Inhibits Brush Border Na+/H+ Exchanger 3 (NHE3) by a NHERF2 Protein-dependent Process
420097	InSolution™ JAK Inhibitor I	Murine JAK1	U87MG-IL6 and U87MG-IRF7 cells	0.5 mM	Interferon regulatory factor 7 regulates glioma stem cells via interleukin-6 and Notch signalling
420097	InSolution™ JAK Inhibitor I	Murine JAK1	Chronic lymphocytic leukemia (CLL) cells	0.15 μg/mL	Leflunomide Induces Apoptosis in Fludarabine-Resistant and Clinically Refractory CLL Cells
681675	Wortmannin	Phosphatidylinositol-3-kinase	C2C12 myoblasts	100 nM	Trpc1 Ion Channel Modulates Phosphatidylinositol 3-Kinase/Akt Pathway during Myoblast Differentiation and Muscle Regeneration
681675	Wortmannin	Phosphatidylinositol-3-kinase	T6.11 cells (HEK293 stably transfected with mouse TRPC6)	10 mM	Involvement of Phosphoinositide 3-Kinase and PTEN Protein in Mechanism of Activation of TRPC6 Protein in Vascular Smooth Muscle Cells
579052	TAPI-2	MMPs and TACE	Neuro2a-hAPP cells	3 mM	The Purinergic Receptor P2X7 Triggers α-Secretase-dependent Processing of the Amyloid Precursor Protein
579052	TAPI-2	MMPs and TACE	NuLi-1 cell line	100 mM	Neuregulin-1-Human Epidermal Receptor-2 Signaling Is a Central Regulator of Pulmonary Epithelial Permeability and Acute Lung Injury
579052	TAPI-2	MMPs and TACE	Given intratracheally to mice	1 mg/kg mouse weight	Neuregulin-1-Human Epidermal Receptor-2 Signaling Is a Central Regulator of Pulmonary Epithelial Permeability and Acute Lung Injury
203390	(±)-Blebbistatin	ATPase	J774A.1 cells	50 mM	The Role of CD38 in Fcγ Receptor (FcγR)-mediated Phagocytosis in Murine Macrophages
203390	(±)-Blebbistatin	ATPase	HUVEC	5 and 10 mM	Epithelial Protein Lost In Neoplasm (EPLIN) Interacts with α-Catenin and Actin Filaments in Endothelial Cells and Stabilizes Vascular Capillary Network in Vitro
364205	GM 6001	MMP-1	Rat hippocampal slice cultures (OHCs)	80 mM	Epileptiform activity interferes with proteolytic processing of Reelin required for dentate granule cell positioning
364205	GM 6001	MMP-1	Human thyroid papillary carcinoma cell lines 8505-C and TPC-1	10 mM	Mitogen-Inducible Gene-6 Is a Multifunctional Adaptor Protein with Tumor Suppressor-Like Activity in Papillary Thyroid Cancer
189490	Autophagy Inhibitor, 3-MA	Class III PI3K inhibitor	THP-1 cells	10 mM	Leukotoxin (Leukothera®) Targets Active Leukocyte Function Antigen-1 (LFA-1) Protein and Triggers a Lysosomal Mediated Cell Death Pathway
189490	Autophagy Inhibitor, 3-MA	Class III PI3K inhibitor	Neuronal cell line NSC34	10 mM	Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy