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Cytoskeletal Structure
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The cytoskeleton consists of actin, microtubules, and intermediate filaments (IFs). Actin polymers, which mediate cell movement and intracellular dynamics, are regulated by signaling proteins, including those of the N-WASP family.
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Microtubules, directing movement of subcellular components, are stabilized by Rho GTPases, microtubule-associated proteins, and organization centers. IFs are a diverse family of structural proteins with equally diverse stabilizing mechanisms. Molecular motor proteins move along actin filaments or microtubules and include myosins, kinesins, and dyneins. These proteins mediate the sliding of filaments and transport organelles along cytoskeletal tracks.
MilliporeSigma provides antibodies and kits for studying components of the cytoskeleton, including actin, vimentin, keratin, neurofilaments, lamin and tubulin, and also provides innovative solutions to investigate signaling proteins that associate with the cytoskeleton.
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Cell Adhesion
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Cell-to-cell and cell-to-extracellular matrix (ECM) adhesion enables cell communication and movement and is critical for the development and maintenance of tissues.
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Adhesion is involved in immune cell migration, metastasis, angiogenesis, wound healing, and other processes. Changes in cell adhesion can be the defining event in diseases such as cancer, osteoporosis, atherosclerosis, and arthritis. Adhesion between tumor cells and their microenvironment involves integrins, matrix metalloproteases (MMPs), and the ECM. Many interactions with the ECM are mediated by integrins, which transduce bidirectional signals controlling cell growth, differentiation, migration, apoptosis and more.
MilliporeSigma offers a wide selection of antibodies against integrins, and other cell-adhesion molecules (CAMs).
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Metalloproteinases and Proteases
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Matrix metalloproteinases (MMPs) are secreted or transmembrane proteolytic endopeptidases that process and degrade extracellular matrix proteins.
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MMPs play critical roles in many normal growth and developmental aspects of tissue remodeling, wound healing, and angiogenesis. In a pathological context, MMPs are associated with cell migration, invasion, arthritis, and cancer tumor progression. Once activated, the MMPs are subject to inhibition by the tissue inhibitors of metalloproteinases (TIMPs) that bind MMPs non-covalently. ADAMs (A Disintegrin And Metalloprotease protein) are members of the same superfamily as MMPs and are cell surface proteins that possess both an adhesion domain as well as a protease domain.
MilliporeSigma offers a full range of MMP antibodies, proteins, and activity assays for interrogating the function and regulation of metalloproteinases (MMPs) in both normal and disease states.
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Cell Visualization
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Cell visualization and microscopy has remained a fundamental tool for investigating cellular behavior and structure, including changes in structural features as well as cellular and sub-cellular dynamics under normal and diseased states.
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As the technology for microscopy has evolved, the ability to interrogate discrete protein and organelle dynamics has increased and the need for specific visualization tools has grown.
MilliporeSigma’s emerging portfolio of biosensors and cell-based assays provide innovative cell visualization and staining tools that complement our suite of fluorescently-conjugated primary and secondary antibodies.
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