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487910 (±)-S-Nitroso-N-acetylpenicillamine - CAS 79032-48-7 - Calbiochem

Nitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC₅₀ = 130 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SNAP

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487910
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
79032-48-7C₇H₁₂N₂O₄S

Products

Catalog NumberPackaging Qty/Pack
487910-1SET Glass bottle 1 set
487910-20MG Plastic ampoule 20 mg
Description
OverviewNitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
Catalogue Number487910
Brand Family Calbiochem®
SynonymsSNAP
References
ReferencesNishio, E., et al. 1996. Biochem. Biophys. Res. Commun. 221, 163.
Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
Fehsel, K., et al. 1995. J. Immunol. 155, 2858.
Gopalkrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther. 248, 762.
Product Information
CAS number79032-48-7
ATP CompetitiveN
FormPale green solid
Hill FormulaC₇H₁₂N₂O₄S
Chemical formulaC₇H₁₂N₂O₄S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNitric oxide donor
Primary Target IC<sub>50</sub>EC50 = 130 nM in relaxation of isolated bovine coronary artery rings
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsSNAP evolves NO immediately upon solubilization; reconstitute just prior to use.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
487910-1SET 04055977200324
487910-20MG 04055977200331

Documentation

(±)-S-Nitroso-N-acetylpenicillamine - CAS 79032-48-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

(±)-S-Nitroso-N-acetylpenicillamine - CAS 79032-48-7 - Calbiochem Certificates of Analysis

TitleLot Number
487910

References

Reference overview
Nishio, E., et al. 1996. Biochem. Biophys. Res. Commun. 221, 163.
Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
Fehsel, K., et al. 1995. J. Immunol. 155, 2858.
Gopalkrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther. 248, 762.

Citations

Title
  • Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision25-October-2016 JSW
    SynonymsSNAP
    DescriptionNitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t1/2 = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Also reported to cause the reversible inactivation of protein kinase C activity. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
    FormPale green solid
    CAS number79032-48-7
    Chemical formulaC₇H₁₂N₂O₄S
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (25 mg/ml), Ethanol (25 mg/ml), or Methanol
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsSNAP evolves NO immediately upon solubilization; reconstitute just prior to use.
    Toxicity Irritant
    ReferencesNishio, E., et al. 1996. Biochem. Biophys. Res. Commun. 221, 163.
    Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
    Fehsel, K., et al. 1995. J. Immunol. 155, 2858.
    Gopalkrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
    Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
    Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther. 248, 762.
    Citation
  • Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277.
    		•