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565755 γ-Secretase Inhibitor II - Calbiochem

The γ-Secretase Inhibitor II controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

γ-Secretase Inhibitor II - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MW167

Primary Target: γ-secretase
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₃₃H₅₇F₂N₅O₉

Products

Catalog NumberPackaging Qty/Pack
565755-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase (IC50 = 13 µM for Aβ). Displays only weak inhibitory activity against calpain II (IC50 = 100 µM in a purified enzyme assay).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number565755
Brand Family Calbiochem®
SynonymsMW167
References
ReferencesWolfe, M.S., et al. 1999. Biochemistry 38, 4720.
Wolfe, M.S., et al. 1998. J. Med. Chem. 41, 6.
Citron, M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13170.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₃H₅₇F₂N₅O₉
Chemical formulaC₃₃H₅₇F₂N₅O₉
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetγ-secretase
Primary Target IC<sub>50</sub>13 µM against γ-secretase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
565755-1MG 04055977267693

Documentation

γ-Secretase Inhibitor II - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

γ-Secretase Inhibitor II - Calbiochem Certificates of Analysis

TitleLot Number
565755

References

Reference overview
Wolfe, M.S., et al. 1999. Biochemistry 38, 4720.
Wolfe, M.S., et al. 1998. J. Med. Chem. 41, 6.
Citron, M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13170.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-November-2014 JSW
SynonymsMW167
DescriptionA cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase with an IC50 of 13 µM for the inhibition of amyloid β-protein (Aβ) production in β-amyloid precursor protein (APP)-transfected Chinese hamster ovary cells. Displays only weak inhibitory activity against calpain II (IC50 = 100 µM in a purified enzyme assay).
FormWhite solid
Chemical formulaC₃₃H₅₇F₂N₅O₉
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mM)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesWolfe, M.S., et al. 1999. Biochemistry 38, 4720.
Wolfe, M.S., et al. 1998. J. Med. Chem. 41, 6.
Citron, M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13170.