Millipore Sigma Vibrant Logo
Attention: We have moved. EMD Millipore products are no longer available for purchase on emdmillipore.com.Learn More

100065 2-APB - CAS 524-95-8 - Calbiochem

A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release.

2-APB - CAS 524-95-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Aminoethoxydiphenylborate, (2-Aminoethoxy)diphenylborane

Primary Target: Ins(1,4,5)P3-induced Ca2+ release
View Products on Sigmaaldrich.com
100065
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
524-95-8C₁₄H₁₆BNO

Products

Catalog NumberPackaging Qty/Pack
100065-100MG Glass bottle 100 mg
Description
OverviewA cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. Inhibits Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations (IC50 = 42 µM) without affecting [3H]-Ins(1,4,5)P3 binding to its receptor. Does not affect Ca2+ release from the ryanodine-sensitive Ca2+ store in rat leg skeletal muscle and heart. Inhibits spontaneous as well as the phasic contractions induced by uterotonic agents. Also reported to inhibit angiotensin II-induced contractions in aortic muscles.
Catalogue Number100065
Brand Family Calbiochem®
Synonyms2-Aminoethoxydiphenylborate, (2-Aminoethoxy)diphenylborane
References
ReferencesBrooke, R. T., et al. 2004. Lab. Invest. 84, 29.
Gregory, R.B., et al. 2001. Biochem. J. 354, 285.
Ma, H.T., et al. 2001. J. Biol. Chem. 276, 18888.
Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun. 264, 979.
Maruyama, T., et al. 1997. J. Biochem. 122, 498.
Product Information
CAS number524-95-8
ATP CompetitiveN
FormWhite crystalline solid
Hill FormulaC₁₄H₁₆BNO
Chemical formulaC₁₄H₁₆BNO
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetIns(1,4,5)P3-induced Ca2+ release
Primary Target IC<sub>50</sub>42 µM against Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations
Purity≥97% by titration
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSED6150000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
100065-100MG 07790788056766

Documentation

2-APB - CAS 524-95-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

2-APB - CAS 524-95-8 - Calbiochem Certificates of Analysis

TitleLot Number
100065

References

Reference overview
Brooke, R. T., et al. 2004. Lab. Invest. 84, 29.
Gregory, R.B., et al. 2001. Biochem. J. 354, 285.
Ma, H.T., et al. 2001. J. Biol. Chem. 276, 18888.
Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun. 264, 979.
Maruyama, T., et al. 1997. J. Biochem. 122, 498.

Citations

Title
  • M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision31-July-2009 RFH
    Synonyms2-Aminoethoxydiphenylborate, (2-Aminoethoxy)diphenylborane
    DescriptionA cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. Inhibits Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations (IC50 = 42 µM) without affecting [3H]-Ins(1,4,5)P3 binding to its receptor. In liver cells, 2-APB inhibits store-operated Ca2+ channels through a mechanism which may involve its binding to either the channel protein or an associated regulatory protein. Has no effect on the Ca2+ release from the ryanodine-sensitive Ca2+ store prepared from rat leg skeletal muscle and heart.
    FormWhite crystalline solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number524-95-8
    RTECSED6150000
    Chemical formulaC₁₄H₁₆BNO
    Structure formulaStructure formula
    Purity≥97% by titration
    SolubilityDMSO (20 mg/ml) and 95% Ethanol (25 mg/ml)
    Storage +2°C to +8°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
    Toxicity Standard Handling
    ReferencesBrooke, R. T., et al. 2004. Lab. Invest. 84, 29.
    Gregory, R.B., et al. 2001. Biochem. J. 354, 285.
    Ma, H.T., et al. 2001. J. Biol. Chem. 276, 18888.
    Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun. 264, 979.
    Maruyama, T., et al. 1997. J. Biochem. 122, 498.
    Citation
  • M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247.
    		•