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SCC731 3dGRO™ Colorectal Organoids (POP.112.G2)

Cryopreserved patient derived colorectal cancer organoids (PDOs)

SCC731
≥ 1500 organoids/vial  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue NumberSCC731
Description3dGRO™ Colorectal Organoids (POP.112.G2)
OverviewColorectal cancer accounts for roughly 10% of all cancer cases worldwide with more than half of all patients with CRC developing metastatic disease leading to death. Recently, tissue derived organoids have emerged as a more predictive 3 dimensional cell culture model of disease. 3D organoid cultures conserve the original genetic and phenotypic characteristics of the primary tissue allowing for their application in many research fields included drug development, personalized medicine and potential therapeutics. In vitro cultured tumor organoids have also been shown to predict patient response to chemotherapeutics. PDOs derived from colorectal cancer (CRC organoids) have been used for cell modeling and to investigate the function of cancer related driver gene mutations including APC, TP53, KRAS, BRAF, PIK3CA etc.

We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids from both normal and diseased patients derived from multiple regions of the digestive systems including small intestine (duodenum, ileum), stomach, rectum and colon.

Cell Line Characteristics
• Sex: Male
• Age: 74 Years
• Organ: Colon (Xenograph from Primary Tumor)
• Disease: Adenocarcinoma (KRAS Mutation: G12A)
Alternate Names
  • Colorectal Cancer Organoid
  • Colon Tumor Organoid
  • Colon Organoid
  • Human CRC Organoids
References
Product Information
Components
  • 1 vial of ≥ 1500 organoids
Quality LevelMQ100
Applications
ApplicationCryopreserved patient derived colorectal cancer organoids (PDOs)
Key Applications
  • Stem Cell Culture
  • Cell Culture
Application Notes3dGRO™ is a trademark of KGaA, Darmstadt, Germany.
3dGRO™ organoids were derived utilizing HUB Organoid Technology.
The purchaser of this product shall agree to HUB’s terms of use, which shall be separately acknowledged and accepted by such purchaser, prior to transfer of this product to purchaser.
Biological Information
HostHuman
Cell Line Type
  • Cancer Cells
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance• Viability: ≥1500 viable organoids/vial
• Organoid Growth: Pass
• Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Mycoplasma Contamination: Negative
• STR Profile: Pass
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore in liquid nitrogen. The organoids can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Packaging Information
Material Size≥ 1500 organoids/vial
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
SCC731 04065269249382