Millipore Sigma Vibrant Logo
Attention: We have moved. EMD Millipore products are no longer available for purchase on emdmillipore.com.Learn More

SCC607 3dGRO™ Human Lung Organoids (PDXO.149)

Cryopreserved Male Squamous Lung Organoids

View Products on Sigmaaldrich.com
SCC607
≥ 1500 organoids/vial   
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue NumberSCC607
Description3dGRO™ Human Lung Organoids (PDXO.149)
Alternate Names
  • Lung PDO
  • Lung Tumor Organoid
  • Airway Organoid
  • Pulmonary Organoid
Background InformationPatient-derived lung organoids (lung PDOs) are adult tissue derived in vitro cultured “mini-lungs” that accurately replicate the histological and functional aspects of in vivo lung tissue. Lung organoids have been shown to contain all 6 major lung epithelial cell types including AEC2s, AEC1s, basal cells, club cells, goblet cells and ciliated cells. These 3D organoid models have become attractive alternatives to traditional PDX and animal lung models to study pulmonary diseases including COPD, cystic fibrosis, SARS-CoV-2, viral infections, asthma, and lung cancer. The 3dGRO™ Human Lung Organoids are high quality cryopreserved cell lines derived from patient-derived xenografts, primary tumors or metastatic patient tissues from various regions of the human lung (acinar, papillary, solid, squamous, mucinous). These lung organoids are highly characterized and express lung airway markers including EPCAM, cytokeratin (CK5, CK7), acetyl-α-tubulin, surfactant proteins (SFTPB/SFTPC), TTF1, P63 and Muc5AC.

Cell Line Characteristics
• Sex: Male
• Age: 62
• Organ: Lung (PDX- Squamous)
• Disease: Squamous Cell Carcinoma (Driver Mutations: PIK3CA AMP)
References
Product Information
HS Code3002 59 00
Quality LevelMQ100
Applications
ApplicationCryopreserved Male Squamous Lung Organoids
Key Applications
  • Cell Culture
  • Stem Cell Culture
Application Notes3dGRO™ is a trademark of KGaA, Darmstadt, Germany.
3dGRO™ organoids were derived utilizing HUB Organoid Technology.
The purchaser of this product shall agree to HUB’s terms of use, which shall be separately acknowledged and accepted by such purchaser, prior to transfer of this product to purchaser.
Biological Information
HostHuman
Cell Line Type
  • Cancer Cells
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance• Each vial contains ≥ 1500 organoids.
• Mycoplasma: Negative
• Genotyped by STR analysis: Pass
• Human species verified
• Organoids are negative for HPV-16, HPV-18, Hepatitis A, B, C, and HIV-1 & 2 viruses by PCR.
• Cell viability test: Pass
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions3dGRO™ human lung organoids should be stored in liquid nitrogen.
Packaging Information
Material Size≥ 1500 organoids/vial
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
SCC607 04065267995151