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393204 4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem

4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: HNE, 4-Hydroxy-2-nonenal

Primary Target: Na+, K+-ATPase activity
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393204
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
75899-68-2C₉H₁₆O₂

Products

Catalog NumberPackaging Qty/Pack
393204-1MG Glass bottle 1 mg
Description
OverviewA major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca2+ and irreversibly inhibits Na+, K+-ATPase activity (IC50 = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK).
Catalogue Number393204
Brand Family Calbiochem®
SynonymsHNE, 4-Hydroxy-2-nonenal
References
ReferencesSoh, Y., et al. 2000. Mol. Pharmacol. 58, 535.
Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772.
Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135.
Siems, W.G., et al. 1996. Free Radic. Res. 20, 215.
Ullrich, O., et al. 1996. Free Radic. Res. 24, 421.
van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.
Product Information
CAS number75899-68-2
ATP CompetitiveN
FormLiquid
FormulationSupplied at 10 mg/ml in ethanol
Hill FormulaC₉H₁₆O₂
Chemical formulaC₉H₁₆O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNa+, K+-ATPase activity
Primary Target IC<sub>50</sub>120 µM against Na+, K+-ATPase activity
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSRA8510000
Safety Information
R PhraseR: 11

Highly flammable.
S PhraseS: 7-16

Keep container tightly closed.
Keep away from sources of ignition - No Smoking.
Product Usage Statements
Storage and Shipping Information
Toxicity Flammable
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
393204-1MG 04055977212471

Documentation

4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem Certificates of Analysis

TitleLot Number
393204

References

Reference overview
Soh, Y., et al. 2000. Mol. Pharmacol. 58, 535.
Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772.
Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135.
Siems, W.G., et al. 1996. Free Radic. Res. 20, 215.
Ullrich, O., et al. 1996. Free Radic. Res. 24, 421.
van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-July-2008 RFH
SynonymsHNE, 4-Hydroxy-2-nonenal
DescriptionA major aldehydic product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages. An inhibitor of State 3 respiration at micromolar levels that causes a transient increase in cytosolic Ca2+. Irreversibly inhibits Na+-K+-ATPase activity (IC50 = 120 µM).
FormLiquid
FormulationSupplied at 10 mg/ml in ethanol
CAS number75899-68-2
RTECSRA8510000
Chemical formulaC₉H₁₆O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityEthanol (10 mg/ml)
Storage ≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Flammable
ReferencesSoh, Y., et al. 2000. Mol. Pharmacol. 58, 535.
Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772.
Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135.
Siems, W.G., et al. 1996. Free Radic. Res. 20, 215.
Ullrich, O., et al. 1996. Free Radic. Res. 24, 421.
van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.