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524394 4α-Phorbol-12,13-didecanoate - CAS 27536-56-7 - Calbiochem

4α-Phorbol-12,13-didecanoate, CAS 27536-56-7, is a negative control for phorbol esters PDD (Cat. No. 524392) & PMA (Cat. No. 524400). Inactive on mouse skin as an inflammatory & tumorigenic agent.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4αPDD, PKC Activator I, Negative Control

Primary Target: A negative control for Phorbol-12,13-didecanoate (PDD) and Phorbol-12-myristate-13-acetate (PMA)
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
27536-56-7C₄₀H₆₄O₈

Products

Catalog NumberPackaging Qty/Pack
524394-1MG Alu drum 1 mg
524394-5MG Alu drum 5 mg
Description
OverviewInactive on mouse skin as an inflammatory and tumor-promoting agent. Useful as a negative control for Phorbol-12,13-didecanoate (PDD; Cat. No. 524392) and Phorbol-12-myristate-13-acetate (PMA; Cat. No. 524400).
Catalogue Number524394
Brand Family Calbiochem®
Synonyms4αPDD, PKC Activator I, Negative Control
References
ReferencesAkiguchi, I., et al. 1993. Endocrinology 138, 379.
Clarke, B.L., et al. 1993. Endocrinology 132, 1168.
Natarajan, V. and Garcia, J.G. 1993. J. Lab. Clin. Med. 121, 337.
Slomiany, B.L., et al. 1992. J. Physiol. Pharmacol. 43, 223.
Product Information
CAS number27536-56-7
ATP CompetitiveN
FormSolid
Hill FormulaC₄₀H₆₄O₈
Chemical formulaC₄₀H₆₄O₈
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Application4α-Phorbol-12,13-didecanoate, CAS 27536-56-7, is a negative control for phorbol esters PDD (Cat. No. 524392) & PMA (Cat. No. 524400). Inactive on mouse skin as an inflammatory & tumorigenic agent.
Biological Information
Primary TargetA negative control for Phorbol-12,13-didecanoate (PDD) and Phorbol-12-myristate-13-acetate (PMA)
Purity>99% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 26/27/28-36/37/38

Very toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-27-36/37/39-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Take off immediately all contaminated clothing.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
524394-1MG 04055977271560
524394-5MG 04055977271577

Documentation

4α-Phorbol-12,13-didecanoate - CAS 27536-56-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

4α-Phorbol-12,13-didecanoate - CAS 27536-56-7 - Calbiochem Certificates of Analysis

TitleLot Number
524394

References

Reference overview
Akiguchi, I., et al. 1993. Endocrinology 138, 379.
Clarke, B.L., et al. 1993. Endocrinology 132, 1168.
Natarajan, V. and Garcia, J.G. 1993. J. Lab. Clin. Med. 121, 337.
Slomiany, B.L., et al. 1992. J. Physiol. Pharmacol. 43, 223.

Brochure

Title
PKC Pathway Poster PDF ( 676 KB )
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-May-2008 RFH
Synonyms4αPDD, PKC Activator I, Negative Control
DescriptionReported to be inactive on mouse skin as an inflammatory and tumor-promoting agent. Used as a negative control for phorbol-12,13-didecanoate (PDD, Cat. No. 524392) and phorbol-12-myristate-13-acetate (PMA, Cat. No. 524400).
FormSolid
Intert gas (Yes/No) Packaged under inert gas
CAS number27536-56-7
Chemical formulaC₄₀H₆₄O₈
Structure formulaStructure formula
Purity>99% by HPLC
SolubilityDMSO or ethanol
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
Toxicity Highly Toxic
ReferencesAkiguchi, I., et al. 1993. Endocrinology 138, 379.
Clarke, B.L., et al. 1993. Endocrinology 132, 1168.
Natarajan, V. and Garcia, J.G. 1993. J. Lab. Clin. Med. 121, 337.
Slomiany, B.L., et al. 1992. J. Physiol. Pharmacol. 43, 223.