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118415 ADP-HPD, Dihydrate, Ammonium Salt - Calbiochem

ADP-HPD, Dihydrate, Ammonium Salt, is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Adenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄

Primary Target: PARG
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O

Products

Catalog NumberPackaging Qty/Pack
118415-1SET Glass bottle 1 set
118415-60UG Plastic ampoule 60 μg
Description
OverviewAn amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration. Also acts as an inhibitor of NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC50 = 260 µM). Note: 1 set = 5 x 60 µg.
Note: 1 set = 5 x 60 µg
Catalogue Number118415
Brand Family Calbiochem®
SynonymsAdenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄
References
ReferencesVispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886.
Slama, J.T., et al. 1995. J. Med. Chem. 38, 389.
Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
Chemical formulaC₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationADP-HPD, Dihydrate, Ammonium Salt, is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM).
Biological Information
Primary TargetPARG
Primary Target IC<sub>50</sub>120 nM against poly(ADP-ribose) glycohydrolase (PARG)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
118415-1SET 04055977224009
118415-60UG 07790788047887

Documentation

ADP-HPD, Dihydrate, Ammonium Salt - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

ADP-HPD, Dihydrate, Ammonium Salt - Calbiochem Certificates of Analysis

TitleLot Number
118415

References

Reference overview
Vispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886.
Slama, J.T., et al. 1995. J. Med. Chem. 38, 389.
Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-October-2007 RFH
SynonymsAdenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄
DescriptionAn amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC50 = 120 nM) vs. ADP-ribose (IC50 = 120 mM). Also inhibits NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC50 = 260 µM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration.
FormWhite lyophilized solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (5 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.
Toxicity Standard Handling
ReferencesVispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886.
Slama, J.T., et al. 1995. J. Med. Chem. 38, 389.
Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.