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121767 AG 1024 - CAS 65678-07-1 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
65678-07-1C₁₄H₁₃BrN₂O

Products

Catalog NumberPackaging Qty/Pack
121767-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.
Catalogue Number121767
Brand Family Calbiochem®
Synonyms3-Bromo-5-t-butyl-4-hydroxy-benzylidenemalonitrile
References
ReferencesWen, B., et al. 2001. Br. J. Cancer 85, 2017.
Parrizas, M., et al. 1997. Endocrinology 138, 1427.
Ohmichi, M., et al. 1993. Biochemistry 32, 4650.
Product Information
CAS number65678-07-1
ATP CompetitiveN
FormOff-white to yellow solid
Hill FormulaC₁₄H₁₃BrN₂O
Chemical formulaC₁₄H₁₃BrN₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetIGF-1
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
121767-1MG 04055977223491

Documentation

AG 1024 - CAS 65678-07-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AG 1024 - CAS 65678-07-1 - Calbiochem Certificates of Analysis

TitleLot Number
121767

References

Reference overview
Wen, B., et al. 2001. Br. J. Cancer 85, 2017.
Parrizas, M., et al. 1997. Endocrinology 138, 1427.
Ohmichi, M., et al. 1993. Biochemistry 32, 4650.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms3-Bromo-5-t-butyl-4-hydroxy-benzylidenemalonitrile
DescriptionA cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases with significantly lower IC50 values for IGF-1 than for insulin receptors. Induces apoptosis by downregulating the expression of phospho-Akt1 and Bcl-2; and increasing the expression of Bax, p53 and p21. Reported to enhance the radiosensitivity of human breast cancer cells.
FormOff-white to yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number65678-07-1
Chemical formulaC₁₄H₁₃BrN₂O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
Toxicity Standard Handling
ReferencesWen, B., et al. 2001. Br. J. Cancer 85, 2017.
Parrizas, M., et al. 1997. Endocrinology 138, 1427.
Ohmichi, M., et al. 1993. Biochemistry 32, 4650.