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658452 AG 126 - CAS 118409-62-4 - Calbiochem

A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages.

AG 126 - CAS 118409-62-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-Cyano-(3-hydroxy-4-nitro)cinnamonitrile

Primary Target: COX-2 activity
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
118409-62-4C₁₀H₅N₃O₃

Products

Catalog NumberPackaging Qty/Pack
658452-5MG Alu drum 5 mg
Description
OverviewA cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate. Reduces the expression of iNOS and COX-2 in lungs of rats treated with carrageenan. Blocks glucocorticoid-induced COX-2 activity in human amnion cells (IC50 = 15.38 µM).
Catalogue Number658452
Brand Family Calbiochem®
Synonymsα-Cyano-(3-hydroxy-4-nitro)cinnamonitrile
References
ReferencesCuzzocrea, S., et al. 2000. Am. J. Pathol. 157, 145.
Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol. 77, 138.
Kan, H., et al. 1996. Mol. Pharmacol. 50, 1139.
Novogrodsky, A., et al. 1994. Science 264, 1319.
Product Information
CAS number118409-62-4
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₀H₅N₃O₃
Chemical formulaC₁₀H₅N₃O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCOX-2 activity
Primary Target IC<sub>50</sub>15.38 µM in blocking glucocorticoid-induced COX-2 activity in human amnion cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 23/24/25

Toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
658452-5MG 04055977261622

Documentation

AG 126 - CAS 118409-62-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AG 126 - CAS 118409-62-4 - Calbiochem Certificates of Analysis

TitleLot Number
658452

References

Reference overview
Cuzzocrea, S., et al. 2000. Am. J. Pathol. 157, 145.
Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol. 77, 138.
Kan, H., et al. 1996. Mol. Pharmacol. 50, 1139.
Novogrodsky, A., et al. 1994. Science 264, 1319.

Brochure

Title
MAPK Pathway Poster ( 750 KB )
Pathways and Biomarkers of Oxidative Stress
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-January-2010 RFH
Synonymsα-Cyano-(3-hydroxy-4-nitro)cinnamonitrile
DescriptionA cell-permeable inhibitor of lipopolysaccaride (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK protein substrate.
FormYellow solid
CAS number118409-62-4
Chemical formulaC₁₀H₅N₃O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMF or DMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Toxic
ReferencesCuzzocrea, S., et al. 2000. Am. J. Pathol. 157, 145.
Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol. 77, 138.
Kan, H., et al. 1996. Mol. Pharmacol. 50, 1139.
Novogrodsky, A., et al. 1994. Science 264, 1319.