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171256 AMPK Activator - CAS 849727-81-7 - Calbiochem

The AMPK Activator, also referenced under CAS 849727-81-7, modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942, AMPK Signaling Activator I

Primary Target: AMPK
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
849727-81-7C₂₂H₂₁FO₄

Products

Catalog NumberPackaging Qty/Pack
171256-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable furancarboxylic acid compound that activates celular AMP-activated protein kinase (AMPK) activity by inhibiting mitochondrial complex I, and thus elevating intracellular AMP level. Shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 µM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Displays negligible cytotoxicity at pharmacological doses.
Catalogue Number171256
Brand Family Calbiochem®
Synonyms5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942, AMPK Signaling Activator I
References
ReferencesKosaka, T., et al. 2005. Anal. Chem. 77, 2050.
Product Information
CAS number849727-81-7
ATP CompetitiveN
FormLight yellow solid
Hill FormulaC₂₂H₂₁FO₄
Chemical formulaC₂₂H₂₁FO₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAMPK
Primary Target IC<sub>50</sub>EC50 = 11.7 µM enhancing glucose uptake in L6 myocytes
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
171256-5MG 04055977207118

Documentation

AMPK Activator - CAS 849727-81-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AMPK Activator - CAS 849727-81-7 - Calbiochem Certificates of Analysis

TitleLot Number
171256

References

Reference overview
Kosaka, T., et al. 2005. Anal. Chem. 77, 2050.

Brochure

Title
New Research Tools for Signal Transduction and Life Science Research
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-April-2008 RFH
Synonyms5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942, AMPK Signaling Activator I
DescriptionA cell-permeable furancarboxylic acid compound that activates celular AMP-activated protein kinase (AMPK) activity by inhibiting mitochondrial complex I, and thus elevating intracellular AMP level. Shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 µM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Displays negligible cytotoxicity at pharmacological doses.
FormLight yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number849727-81-7
Chemical formulaC₂₂H₂₁FO₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesKosaka, T., et al. 2005. Anal. Chem. 77, 2050.