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531978 ATM Inhibitor, KU 60019 - CAS 925701-46-8 - Calbiochem

ATM kinase inhibitor, KU60019, is a cell permeable, potent inhibitor of ATM kinase inhibitor (IC₅₀ = 6.3 nM). Has 270 & 1600-fold higher selectivity over DNA-PK and ATR kinase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: KU-60019, KU60019, Ataxia Telangiectasia Mutate Kinase Inhibitor

Primary Target: ATM
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
925701-46-8C₃₀H₃₃N₃O₅S

Products

Catalog NumberPackaging Qty/Pack
5.31978.0001 Glass bottle 10 mg
Description
OverviewA cell permeable thioxanthene based compound that acts as a highly potent inhibitor of Ataxia telangiectasia mutate (ATM) kinase inhibitor (IC50 = 6.3 nM). Displays about 270 and 1600-fold greater selectivity over DNA-PK and ATR kinase (IC50 = 1.7 and >10 µM, respectively). Has only a trivial effect on 229 protein kinases when screened in a panel at 1 µM level. Shown to block Ser15 phosphorylation of p53 and basal and radiation-induced Ser473 phosphorylation of Akt in glioma cells. Blocks radiation-induced DNA damage response and radiosensitizes human glioma cells (U87 and U1242) and mouse glioma stem cells and inhibits glioma cell migration, invasion, and growth. Also radiosensitizes orthotopic glioma xenografts and significantly extends the survival of mice.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number531978
Brand Family Calbiochem®
SynonymsKU-60019, KU60019, Ataxia Telangiectasia Mutate Kinase Inhibitor
References
ReferencesBiddlestone-Thorpe, L., et al. 2013. Clin. Cancer Res. 19, 3189.
Golding, S., et al. 2009. Mol. Cancer Ther. 8, 2894.
Product Information
CAS number925701-46-8
FormLight beige solid
Hill FormulaC₃₀H₃₃N₃O₅S
Chemical formulaC₃₀H₃₃N₃O₅S
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetATM
Primary Target IC<sub>50</sub>6.3 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.31978.0001 04055977287127

Documentation

ATM Inhibitor, KU 60019 - CAS 925701-46-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Biddlestone-Thorpe, L., et al. 2013. Clin. Cancer Res. 19, 3189.
Golding, S., et al. 2009. Mol. Cancer Ther. 8, 2894.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-November-2015 JSW
SynonymsKU-60019, KU60019, Ataxia Telangiectasia Mutate Kinase Inhibitor
DescriptionA cell permeable thioxanthene based compound that acts as a highly potent inhibitor of Ataxia telangiectasia mutate (ATM) kinase inhibitor (IC50 = 6.3 nM). Displays about 270 and 1600-fold greater selectivity over DNA-PK and ATR kinase (IC50 = 1.7 and >10 µM, respectively). Has only a trivial effect on 229 protein kinases when screened in a panel at 1 µM level. Shown to block Ser15 phosphorylation of p53 and basal and radiation-induced Ser473 phosphorylation of Akt in glioma cells. Blocks radiation-induced DNA damage response and radiosensitizes human glioma cells (U87 and U1242) and mouse glioma stem cells and inhibits glioma cell migration, invasion, and growth. Also radiosensitizes orthotopic glioma xenografts and significantly extends the survival of mice.
FormLight beige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number925701-46-8
Chemical formulaC₃₀H₃₃N₃O₅S
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBiddlestone-Thorpe, L., et al. 2013. Clin. Cancer Res. 19, 3189.
Golding, S., et al. 2009. Mol. Cancer Ther. 8, 2894.