114825 Sigma-AldrichAdapalene - CAS 106685-40-9 - Calbiochem
A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα.
More>> A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα. Less<<Adapalene - CAS 106685-40-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: CD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271
Recommended Products
Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 106685-40-9 | C₂₈H₂₈O₃ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 114825-25MG | 25 mg |
| Description | |
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| Overview | A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo. |
| Catalogue Number | 114825 |
| Brand Family | Calbiochem® |
| Synonyms | CD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271 |
| Product Information | |
|---|---|
| CAS number | 106685-40-9 |
| Form | White solid |
| Hill Formula | C₂₈H₂₈O₃ |
| Chemical formula | C₂₈H₂₈O₃ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥97% by HPLC |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 114825-25MG | 04055977208122 |
Documentation
Adapalene - CAS 106685-40-9 - Calbiochem SDS
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Adapalene - CAS 106685-40-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 114825 |
References
| Reference overview |
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| Irby, C.E., et al. 2008. J. Adolesc. Health 43, 421. Ocker, M., et al. 2003. Int. J. Cancer 107, 453. Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349. Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96. |
Brochure
| Title |
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| Undisputed Accuracy for Your Quantitative Results |
Technical Info
| Title |
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| Programming data for Spectrophotometer and Spectroquant Test Kits |
User Guides
| Title |
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| Manual Spectroquant Multy - Operating manual |
| Quick Guide Spectroquant Photometer NOVA 60A (EN, DE, FR, ES, IT) |
| User Guide (IFU) - 1.14825 |