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505855 Adenovirus Proteinase Inhibitor, NSC 37249 - CAS 2907-88-2 - Calbiochem

An inhibitor of adenovirus cysteine proteinase AVP that simultaneously targets AVP co-factor pVIc N-terminal binding pocket (Ki = 150 nM) and AVP-pVIc substrate-binding site (Ki = 400 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: AVP Inhibitor, 2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,Nʹ-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide

Primary Target: AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
2907-88-2C₄₀H₅₈N₄O₄S

Products

Catalog NumberPackaging Qty/Pack
5.05855.0001 Glass bottle 10 mg
Description
OverviewA sulfonyldiphenylene-bis-dicyclohexylaminoacetamide compound that acts as a potent and selective inhibitor against adenovirus cysteine proteinase AVP by targeting simultaneously AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket (Ki = 150 nM) and AVP-pVIc substrate-binding site (Ki = 400 nM), blocking both AVP-pVIc active complex formation (IC50 = 140 nM; [substrate] = 5 µM & [pVIc] = 40 µM) and catalytic activity (IC50 = 490 nM; [substrate] = 5 µM) without affecting trypsin or papain protease activity even at concentrations as high as 10 µM.
Catalogue Number505855
Brand Family Calbiochem®
SynonymsAVP Inhibitor, 2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,Nʹ-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide
References
ReferencesMcGrath, W.J., et al. 2013. FEBS Lett. 587, 2332.
Product Information
CAS number2907-88-2
FormOff-white powder
Hill FormulaC₄₀H₅₈N₄O₄S
Chemical formulaC₄₀H₅₈N₄O₄S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket
Secondary targetAVP-pVIc substrate-binding site
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.05855.0001 04055977263091

Documentation

Adenovirus Proteinase Inhibitor, NSC 37249 - CAS 2907-88-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
McGrath, W.J., et al. 2013. FEBS Lett. 587, 2332.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-January-2014 JSW
SynonymsAVP Inhibitor, 2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,Nʹ-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide
DescriptionA sulfonyldiphenylene-bis-dicyclohexylaminoacetamide compound that acts as a potent and selective inhibitor against adenovirus AVP, the cysteine proteinase critical for virion assembly and maturation, by targeting simultaneously AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket (Ki = 150 nM) and AVP-pVIc substrate-binding site (Ki = 400 nM), blocking not only AVP-pVIc active complex formation/AVP activation (IC50 = 140 nM; [substrate] = 5 µM & [pVIc] = 40 µM), but also AVP-pVIc active complex catalytic activity (IC50 = 490 nM; [substrate] = 5 µM). Does not affect the activity of the serine protease trypsin or the cysteine protease papain even at concentrations as high as 10 µM.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number2907-88-2
Chemical formulaC₄₀H₅₈N₄O₄S
Structure formulaStructure formula
Purity≥90% by HPLC
Solubility5% TFA in EtOH (5 mg/ml). Not soluble in DMSO.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesMcGrath, W.J., et al. 2013. FEBS Lett. 587, 2332.