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MABC1213 Anti-AMHR2 Antibody, clone 10H8.1

Detect AMHR2 using this mouse monoclonal Anti-AMHR2 Antibody, clone 10H8.1, Cat. No. MABC1213, validated for use in Western Blotting.

Anti-AMHR2 Antibody, clone 10H8.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Gene Symbol: AMHR2, AMHR, MISR2 UniProt Number: Q16671
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MABC1213
100 μg  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC1213
DescriptionAnti-AMHR2 Antibody, clone 10H8.1
Alternate Names
  • Anti-Muellerian hormone type-2 receptor
  • Anti-Muellerian hormone type II receptor
  • AMH type II receptor
  • MIS type II receptor
  • MISRII
  • MRII
Background InformationAnti-Muellerian hormone type-2 receptor (EC 2.7.11.30; UniProt Q16671; also known as Anti-Muellerian hormone type II receptor, AMH type II receptor, MIS type II receptor, MISRII, MRII) is encoded by the AMHR2 (also known as AMHR, MISR2) gene (Gene ID 269) in human. Anti-Müllerian hormone (AMH) or Müllerian inhibiting substance (MIS) is a TGF- family homodimeric glycoprotein hormone. AMH/MIS is responsible for regression of the Müllerian ducts in male embryos, it is also produced in both male and female gonads after birth and plays a role in folliculogenesis, germ cell maturation and gonadal function. AMH/MIS interacts with single membrane-spanning serine/threonine kinase receptors type I (AMHR1/MISRI) and II (AMHR2/MISRII). AMHR1 is nearly ubiquitously expressed, whereas AMHR2 is mainly detected in the gonads and other organs of the reproductive tract. AMHR2 is found expressed in the majority of human granulosa cell tumors (GCTs) and epithelial ovarian cancers (EOCs). In addition, AMHR2 expression is also reported in breast and prostate cancers. Human AMHR2 is produced with a signal peptide (a.a. 1-17), which is removed posttranslationally to yield the mature receptor with an N-terminal extracellular region (a.a. 18-149), a singl-transmembrane domain (a.a. 150-170), and a large cytoplasmic region (a.a. 171-573) that contains the kinase domain (a.a. 203-518; a.a. 230 ATP-binding site; a.a. 333 proton acceptor site; a.a. 209-217 ATP-binding site).
References
Product Information
FormatPurified
PresentationPurified mouse IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect AMHR2 using this mouse monoclonal Anti-AMHR2 Antibody, clone 10H8.1, Cat. No. MABC1213, validated for use in Western Blotting.
Key Applications
  • Western Blotting
Biological Information
ImmunogenGST-tagged recombinant human AMHR2 extracellular domain.
Clone10H8.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone 10H8.1 targets an extracellular epitope present in all three spliced isoforms of human AMH type II receptor (AMHR2) reported by UniProt (Q16671).
IsotypeIgG2aκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • AMHR2
  • AMHR
  • MISR2
Purification MethodProtein G purified.
UniProt Number
Molecular Weight~60 kDa observed. 62.75/52.24/51.83 kDa (isoform 1/2/3) calculated. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected AMHR2 in 10 µg of Jurkat cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
MABC1213 04054839057212