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MAB4350 Anti-BMP-7 Antibody, clone 2A10

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MAB4350
100 µg  
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Overview

Replacement Information

Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, IHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB4350
DescriptionAnti-BMP-7 Antibody, clone 2A10
Background InformationBone morphogenetic protein-7 (BMP-7), also known as osteogenic protein-1, is a member of the TGF- superfamily, and is widely expressed during embryonic development. Like other members of the bone morphogenetic protein family, BMP-7 works synergistically with BMP-2 to play a key role in the differentiation of mesenchymal cells into bone and cartilage tissues by actively recruiting stem cells from the surrounding tissue, thereby initiating the bone formation cascade. In adult cells, BMP-7 is predominately expressed in the brain, kidneys, and bladder.
References
Product Information
FormatPurified
HS Code3002 15 90
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4),
150 mM NaCl, and 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-BMP-7 Antibody, clone 2A10 is validated for use in WB, IH for the detection of BMP-7.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry: Recommended working dilution is 1:50.

Western Blotting: Recommended working concentration is 1 – 2 µg/mL.
Biological Information
ImmunogenRecombinant full-length BMP-7 protein.
Clone2A10
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityThis monoclonal antibody recognizes BMP-7.
IsotypeIgG1κ
Species Reactivity
  • Human
  • Mouse
Species Reactivity NoteReacts with human and mouse. Reactivity with other species has not been tested.
Antibody TypeMonoclonal Antibody
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFunction Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
Subunit structure Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 By similarity.
Subcellular location Secreted.
Tissue specificity Expressed in the kidneys and bladder. Lower levels seen in the brain.
Post-translational modification Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (Ref.5).
Pharmaceutical use Available under the names Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.
Sequence similarities Belongs to the TGF-beta family.
Stem Cell Type
  • Mesenchymal Stem Cells
Molecular Weight46 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeat freeze/thaw cycles.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
MAB4350 04053252505072

Documentation

Anti-BMP-7 Antibody, clone 2A10 SDS

Title

Safety Data Sheet (SDS) 

Anti-BMP-7 Antibody, clone 2A10 Certificates of Analysis

TitleLot Number
Anti-BMP-7, clone 2A10 - 2410229 2410229
Anti-BMP-7, clone 2A10 - 2297027 2297027
Anti-BMP-7, clone 2A10 - 3510791 3510791
Anti-BMP-7, clone 2A10 - 3850505 3850505
Anti-BMP-7, clone 2A10 - 4136841 4136841
Anti-BMP-7, clone 2A10 - LV1716344 LV1716344
Anti-BMP-7, clone 2A10 - NG1618275 NG1618275
Anti-BMP-7, clone 2A10 - NG1922987 NG1922987
Anti-BMP-7, clone 2A10 -2589603 2589603
Anti-BMP-7, clone 2A10 -2608151 2608151

References

Reference overviewPub Med ID
Three-dimensional epithelial and mesenchymal cell co-cultures form early tooth epithelium invagination-like structures: expression patterns of relevant molecules.
Li Xiao,Takeki Tsutsui
Journal of cellular biochemistry  113  2012

Show Abstract
22234822 22234822
Oral administration of recombinant adeno-associated virus-mediated bone morphogenetic protein-7 suppresses CCl(4)-induced hepatic fibrosis in mice.
Hao, ZM; Cai, M; Lv, YF; Huang, YH; Li, HH
Molecular therapy : the journal of the American Society of Gene Therapy  20  2043-51  2012

Show Abstract
22850680 22850680