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ABC149 Anti-BST2 Antibody

Anti-BST2 is an antibody targeting the BST2 protein, validated for use in WB & IHC.

Anti-BST2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: BST2 UniProt Number: Q10589
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ABC149
100 µg  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC149
ReplacesMABF201
DescriptionAnti-BST2 Antibody
Alternate Names
  • Bone marrow stromal antigen 2
  • BST-2
  • HM1.24 antigen
  • Tetherin
Background InformationBST-2 also known as CD317 and Tetherin, bone marrow stromal antigen 2 (BST-2) is an interferon-inducible transmembrane protein that potently inhibits the release of nascent retrovirus particles. BST-2 is downregulated by the viral Vpu protein. BST-2 acts as a direct physical tether, which holds and links virions at the cell membrane. These tethered virons can remain on the cell surface or be internalized by endocytosis for degradation. BST-2 inhibits MMP2 and MMP15 activity, resulting in the attenuation of cellular proliferation and migration. BST-2 interaction with LILRA/ILT7 receptors in plasmacytoid dendritic cells negatively regulates IFN production in response to viral infection.
References
Product Information
FormatAffinity Purified
Control
  • Human bone marrow tissue lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-BST2 is an antibody targeting the BST2 protein, validated for use in WB & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected BST2 in human cardiac myocyte and human hepatocyte tissues.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the extracellular domain of human BST2.
Epitopeextracellular domain
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes the extracellular domain of BST2
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • BST2
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~33 kDa observed. The calculated molecular weight of this protein is 20 kDa, but can be observed at ~25-35 kDa due to high glycosylation.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in human bone marrow tissue lysate.

Western Blot Analysis: 1.0 µg/mL of this antibody detected BST2 in 10 µg of human bone marrow tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
ABC149 04053252832468