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MABF1719 Anti-CD4 (human), PE, clone RPA-T4 Antibody

This Anti-CD4 (human), PE, clone RPA-T4 Antibody is validated for use in Flow Cytometry for the detection of CD4.

Anti-CD4 (human), PE, clone RPA-T4 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: CD4 UniProt Number: P01730
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MABF1719
100 tests  
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Overview

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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFCMPEMonoclonal Antibody
Description
Catalogue NumberMABF1719
DescriptionAnti-CD4 (human), PE, clone RPA-T4 Antibody
Alternate Names
  • T-cell surface glycoprotein CD4
  • T-cell surface antigen T4/Leu-3
  • CD antigen CD4
  • CD4
Background InformationThe RPA-T4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The RPA-T4 antibody is widely used as a phenotypic marker for human CD4 expression, and is cross-reactive with Chimpanzee CD4. This antibody recognizes a different epitope, and thus does not block binding of, the alternative Anti-Human CD4 antibody clone OKT4 (Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061-4065).
References
Product Information
FormatPE
PresentationPurified Mouse monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
Quality LevelMQ100
Applications
ApplicationThis Anti-CD4 (human), PE, clone RPA-T4 Antibody is validated for use in Flow Cytometry for the detection of CD4.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenImmunogen information for this antibody is proprietary information.
CloneRPA-T4
ConcentrationPlease refer to lot specific datasheet.
HostMouse
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Gene Symbol
  • CD4
Purification MethodPurified by size-exclusion chromatography
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceThis monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.5 μg from a representative lot detected CD4 in one million human peripheral blood lymphocytes.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Packaging Information
Material Size100 tests
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
MABF1719 04055977290226

Documentation

Anti-CD4 (human), PE, clone RPA-T4 Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-CD4 (human), PE, clone RPA-T4 Antibody Certificates of Analysis

TitleLot Number
Anti-CD4 (human), PE, clone RPA-T4 - VP1901032 VP1901032
Anti-CD4 (human), PE, clone RPA-T4 - VP1907243 VP1907243
Anti-CD4 (human), PE, clone RPA-T4 - VP2206081 VP2206081
Anti-CD4 (human), PE, clone RPA-T4 - VP2301053 VP2301053
Anti-CD4 (human), PE, clone RPA-T4 - VP2304045 VP2304045
Anti-CD4 (human), PE, clone RPA-T4 - VP2401252 VP2401252
Anti-CD4 (human), PE, clone RPA-T4 -QVP1508184 QVP1508184
Anti-CD4 (human), PE, clone RPA-T4 Monoclonal Antibody VP1809241
Anti-CD4 (human), PE, clone RPA-T4 Monoclonal Antibody VP2111116

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Categories

Life Science Research > Antibodies and Assays > Primary Antibodies