Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
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Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
-Phospho-specific and total MAPmate™ pairs, e.g. total GSK3β and GSK3β (Ser 9)
-PanTyr and site-specific MAPmates™, e.g. Phospho-EGF Receptor and phospho-STAT1 (Tyr701)
-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
-GAPDH and β-Tubulin cannot be plexed with kits or MAPmates™ containing panTyr
.
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48-602MAG
Buffer Detection Kit for Magnetic Beads
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Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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PC711
Sigma-AldrichAnti-CHIP Rabbit pAb
This Anti-CHIP Rabbit pAb is validated for use in Immunoblotting for the detection of CHIP.
More>>This Anti-CHIP Rabbit pAb is validated for use in Immunoblotting for the detection of CHIP. Less<<
Anti-CHIP Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Recognizes the ~35 kDa CHIP protein. May also detect bands at ~43, ~51, and ~70 kDa corresponding to the mono-ubiquitinated, di-ubiquitinated, and dimeric forms of CHIP, respectively.
Catalogue Number
PC711
Brand Family
Calbiochem®
Synonyms
Anti-Carboxyl Terminus of Hcs70-Interacting Protein
References
References
Xu, W., et al. 2002. Proc. Natl. Acad. Sci. USA99, 12847. Demand, J., et al. 2001. Curr. Biol.11, 1569. Connell, P., et al. 2001. Nat. Cell Biol.3, 93. Jiang. J., et al. 2001. J. Biol. Chem. 276, 42938. Meacham, G.C., et al. 2001. Nat. Cell. Biol.3, 100. Ballinger, C.A., et al. 1999. Mol. Cell. Biol.19, 4535.
May also detect bands at 43, 51, and 70 kDa, wich correspond to the mono-ubiquitinated, di-ubiquitinated, and dimeric forms of CHIP, respectively. Antibody should be titrated for optimal results in individual systems.
Biological Information
Immunogen
a recombinant protein consisting of full-length human CHIP fused to a His•Tag® sequence
Host
Rabbit
Isotype
IgG
Species Reactivity
Drosophila
Hamster
Human
Monkey
Mouse
Rat
Antibody Type
Polyclonal Antibody
Storage and Shipping Information
Ship Code
Dry Ice Only
Toxicity
Standard Handling
Storage
-20°C
Avoid freeze/thaw
Avoid freeze/thaw
Do not freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-20°C).
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
11-October-2018 JSW
Synonyms
Anti-Carboxyl Terminus of Hcs70-Interacting Protein
Rabbit polyclonal antibody supplied as undiluted serum. Recognizes the ~35 kDa CHIP protein.
Background
CHIP is a U-box dependent E3 ubiquitin ligase and a co-chaperone protein that interacts with Hsc70 and Hsp90 regulating protein triage decisions between folding and degradation. This occurs through CHIP remodeling the complexes to favor substrate degradation thus providing a molecular link between the chaperone and proteosome machinery. CHIP has been reported to be involved in the degradation of c-ErbB2/c-Neu, the glucocorticoid receptor, and the cystic fibrosis transmembrane-conductance regulator. CHIP expression shortens the half-life of both the nascent and mature ErbB2 protein.
Host
Rabbit
Immunogen
a recombinant protein consisting of full-length human CHIP fused to a His•Tag® sequence
Isotype
IgG
Species
Drosophila, hamster, human, monkey, mouse, rat
Positive control
COS-7 cells
Form
Liquid
Formulation
Undiluted serum.
Preservative
≤0.1% Sodium azide
Comments
May also detect bands at 43, 51, and 70 kDa, wich correspond to the mono-ubiquitinated, di-ubiquitinated, and dimeric forms of CHIP, respectively. Antibody should be titrated for optimal results in individual systems.
Storage
Avoid freeze/thaw
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-20°C).
Toxicity
Standard Handling
References
Xu, W., et al. 2002. Proc. Natl. Acad. Sci. USA99, 12847. Demand, J., et al. 2001. Curr. Biol.11, 1569. Connell, P., et al. 2001. Nat. Cell Biol.3, 93. Jiang. J., et al. 2001. J. Biol. Chem. 276, 42938. Meacham, G.C., et al. 2001. Nat. Cell. Biol.3, 100. Ballinger, C.A., et al. 1999. Mol. Cell. Biol.19, 4535.