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ABT543 Anti-Claudin-4 Antibody

This Anti-Claudin-4 Antibody is validated for use in Western Blotting_x000D_ and Immunocytochemistry for the detection of Claudin-4.

Anti-Claudin-4 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: CLDN4, CPER, CPETR1, WBSCR8 UniProt Number: O14493
ABT543
100 μg  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, ICCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABT543
DescriptionAnti-Claudin-4 Antibody
Alternate Names
  • Claudin-4
  • Clostridium perfringens enterotoxin receptor
  • CPE-R
  • CPE-receptor
  • Williams-Beuren syndrome chromosomal region 8 protein
Background InformationClaudin 4, also known as Clostridium perfringens enterotoxin receptor, or CPE-R, or CPE-receptor or Williams-Beuren syndrome chromosomal region 8 protein, and encoded by the gene CLDN4/CPER/CPETR1/WBSCR8, plays a critical role in tight junction specific obliteration of intercellular space. Claudin 4 directly interacts with several important tight junction associated proteins including ZO-1,2,3 and EPHA2 proteins, and through these interactions, Claudin 4 regulates tight junction formation. Claudin 4 is localized to cell junctions and membranes at tight junctions. Claudin 4 is expressed in most tissues particularly in intestine, liver, and pancreas. Defects in Claudin 4 may be associated with Williams Beuren syndrome genetic deletion syndrome. Claudin 4 is also over expressed in many cancers and thus is a target of anti-cancer research using C. perfringens enterotoxin.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide.
Quality LevelMQ300
Applications
ApplicationThis Anti-Claudin-4 Antibody is validated for use in Western Blotting_x000D_ and Immunocytochemistry for the detection of Claudin-4.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesImmunocytochemistry Analysis (ICC): 20 μg/mL from a representative lot detected Claudin-4 in human colon tissue.
Biological Information
ImmunogenClaudin-4 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human Claudin-4.
EpitopeNear C-terminus
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • CLDN4
  • CPER
  • CPETR1
  • WBSCR8
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~58 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human colon tissue lysate.

Western Blotting Analysis (WB): 1 μg/mL of this antibody detected Claudin-4 in human colon tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
ABT543 04055977174717