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AB5840-I-25UG Anti-Dab1

Anti-Dab1, Cat. No. AB5840-I, is a highly specific rabbit polyclonal antibody that targets Disabled homolog 1 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-Dab1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: Dab1 UniProt Number: P97318
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AB5840-I-25UG
25 μg  
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Overview

Replacement Information

Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
MWB, IH(P)RbPurifiedPolyclonal Antibody
Description
Catalogue NumberAB5840-I-25UG
DescriptionAnti-Dab1
Alternate Names
  • Disabled homolog 1
Background InformationDisabled homolog 1 (UniProt: P97318; also known as DAB1) is encoded by the Dab1 gene (Gene ID: 13131) in murine species. Dab 1 is mainly expressed in the brain and serves as an adapter molecule involved in neural development where it is reported to direct the migration of cortical neurons past previously formed neurons to reach their proper layer. DAB1 is can be phosphorylated on Tyr198, Tyr220, and Tyr232 upon reelin induction in embryonic neurons. It can also be phosphorylated on Ser524, but this phosphorylation is independent of reelin signaling. Tyrosine phosphorylation of DAB1 by Src family tyrosine kinases is considered to be the most critical downstream event in Reelin signaling. DAB1 contains a phosphotyrosine interaction domain (PID) (aa 36-189), which specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins. Seven different isoforms of Dab1 have been identified that are generated via alternative splicing.
References
Product Information
FormatPurified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
ApplicationAnti-Dab1, Cat. No. AB5840-I, is a highly specific rabbit polyclonal antibody that targets Disabled homolog 1 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Dab1 in mouse cerebral cortex tissue sections.
Biological Information
ImmunogenGST-tagged recombinant fragment corresponding to 156 amino acids from the C-terminal half of murine Disabled homolog 1 (Dab1).
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThis rabbit polyclonal antibody detects murine Disabled homolog 1 (Dab1). It targets an epitope within 156 amino acids from the C-terminal half.
Species Reactivity
  • Mouse
Species Reactivity NoteMouse.
Antibody TypePolyclonal Antibody
Gene Symbol
  • Dab1
Purification MethodAffinity Purified
UniProt Number
Molecular Weight~64 kDa observed; 63.58 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in mouse brain tissue lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected Dab1 in 10 µg of m ouse brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size25 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
AB5840-I-25UG 04054839518683