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MABS62 Anti-GREB1 Antibody, clone GREB1Ab

This Anti-GREB1 Antibody, clone GREB1Ab is validated for use in WB, IH, IC for the detection of GREB1.

Anti-GREB1 Antibody, clone GREB1Ab MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling, Apoptosis & Cancer Research Sub-Category: Hormones & Receptors Gene Symbol: GREB1 UniProt Number: Q4ZG55
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MABS62
100 µg  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHC, ICCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABS62
DescriptionAnti-GREB1 Antibody, clone GREB1Ab
Alternate Names
  • growth regulation by estrogen in breast cancer 1
  • Gene regulated in breast cancer 1 protein
  • protein GREB1
  • gene regulated by estrogen in breast cancer protein
Background InformationGREB1, also known as gene regulated in breast cancer protein 1 is shown to be involved in the proliferation of breast cancer cells, controlled by estrogen. GREB1 has the potential to be a clinical marker for response to endocrine therapy and a therapeutic target. GREB1 also may be the regulator for prostate cancer.
References
Product Information
FormatPurified
Control
  • MCF-7 cell lysate
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-GREB1 Antibody, clone GREB1Ab is validated for use in WB, IH, IC for the detection of GREB1.
Key Applications
  • Western Blotting
  • Immunohistochemistry
  • Immunocytochemistry
Application NotesImmunohistochemistry Analysis: 1:600 dilution from a previous lot detected GREB1 in prostate tissue.

Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IP. (Hnatyszyn, H., et al. 2009). Breast Cancer Res Treat
DOI 10.1007/s10549-009-0584-x.)
Biological Information
ImmunogenRecombinant protein corresponding to human GREB1.
CloneGREB1Ab
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq].
Gene Symbol
  • GREB1
Purification MethodProtein G
UniProt Number
UniProt SummaryFUNCTION: Unknown. Primary target for estrogen receptor regulation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.

SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).

TISSUE SPECIFICTY: Expressed in proliferating prostatic tissue and prostate cancer.

INDUCTION: Estrogen-responsive; regulated by estrogen receptors. Regulated by androgens. The regulatory region of the gene contains 3 estrogen-responsive elements.

SEQUENCE SIMILARITIES: Belongs to the GREB1 family.

SEQUENCE CAUTION: The sequence BAA25501.2 differs from that shown. Reason: Erroneous initiation.
Molecular Weight~ 216 kDa observed. Uncharacterized bands may be observed in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in MCF-7 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected GREB1 on 10 µg of MCF-7 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
MABS62 04053252290961

Documentation

Anti-GREB1 Antibody, clone GREB1Ab SDS

Title

Safety Data Sheet (SDS) 

Anti-GREB1 Antibody, clone GREB1Ab Certificates of Analysis

TitleLot Number
Anti-GREB1, clone GREB1Ab 2480867
Anti-GREB1, clone GREB1Ab - 2376462 2376462
Anti-GREB1, clone GREB1Ab - 2433588 2433588
Anti-GREB1, clone GREB1Ab - 1976938 1976938
Anti-GREB1, clone GREB1Ab - 2316556 2316556
Anti-GREB1, clone GREB1Ab - 2842536 2842536
Anti-GREB1, clone GREB1Ab - 3445074 3445074
Anti-GREB1, clone GREB1Ab - 3903320 3903320
Anti-GREB1, clone GREB1Ab - 3978880 3978880
Anti-GREB1, clone GREB1Ab - 4079396 4079396
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