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MABN642 Anti-GST Omega 1 (GSTO1), clone 1H10.1 Antibody

This Anti-GST Omega 1 (GSTO1), clone 1H10.1 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of GST Omega 1 (GSTO1).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: GSTO1, GSTTLP28 UniProt Number: P78417
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MABN642
100 µg  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RWB, IH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN642
DescriptionAnti-GST Omega 1 (GSTO1), clone 1H10.1 Antibody
Alternate Names
  • Glutathione S-transferase omega-1
  • GSTO-1
  • Glutathione S-transferase omega 1-1
  • GSTO 1-1
  • Glutathione-dependent dehydroascorbate reductase
  • Monomethylarsonic acid reductase
  • MMA(V) reductase
  • S-(Phenacyl)glutathione reductase
  • SPG-R
  • GST Omega 1 (GSTO1)
Background InformationGST Omega 1 (GSTO1), also known as Glutathione S-transferase omega-1,GSTO-1, Glutathione S-transferase omega 1-1, GSTO 1-1, Glutathione-dependent dehydroascorbate reductase, Monomethylarsonic acid reductase, MMA(V), or S-(Phenacyl)glutathione reductase, SPG-R, and encoded by the gene GSTO1/GSTTLP28, a ubiquitously expressed cytoplasmic enzyme that is highest in the liver and lowest in the brain It belongs to the GST superfamily of anti-oxidant reducing enzymes and is in the omega class. The omega class of glutathione transferases (GSTs) is a relatively ancient member of the cytosolic GST superfamily, and the omega-class GSTs are found in plants, animals, and some microbial species. The omega-class, unlike other GSTs, has a cysteine residue in their active site. Consequently, the omega-class GSTs catalyze a range of thiol transferase and reduction reactions that are not catalyzed by members of the other classes. GST Omega 1 (GSTO1) is involved in L-ascorbic acid metabolism, detoxification of arsenic substances, glutathione biosynthetic processes, regulation of ryanodine-sensitive calcium release channels, regulation of skeletal muscle contraction and the release of sequestered calcium in muscle, and xenobiotic catabolism. Interestingly genetic linkage studies have discovered associations between GSTO1 gene mutations and the age at onset of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, perhaps stemming from the capacity of omega-class GSTs to mitigate oxidative stress or their role in activating the proinflammatory cytokine, interleukin-1β.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-GST Omega 1 (GSTO1), clone 1H10.1 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of GST Omega 1 (GSTO1).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:50-500 dilution from a representative lot detected GST Omega 1 (GSTO1) in human cerebral cortex and rat cerebellum tissue.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to human GST Omega 1 (GSTO1).
Clone1H10.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • GSTO1
  • GSTTLP28
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~28 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human heart tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected GST Omega 1 (GSTO1) in 200 µg of human heart tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
MABN642 04053252978852