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MABE988 Anti-Homeobox protein CDX-2 Antibody, clone 7D9.1

This Anti-Homeobox protein CDX-2 Antibody, clone 7D9.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Homeobox protein CDX-2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: CDX2, CDX3 UniProt Number: Q99626
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MABE988
100 μg  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABE988
DescriptionAnti-Homeobox protein CDX-2 Antibody, clone 7D9.1
Alternate Names
  • Homeobox protein CDX-2
  • Homeobox protein CDX-2
  • CDX-3
  • Caudal-type homeobox protein 2
Background InformationHomeobox protein CDX-2 (UniProt Q99626; also known as Caudal-type homeobox protein 2, Caudal type homeobox transcription factor 2, CDX-3) is encoded by the CDX2 (also known as CDX3, CDX2/AS) gene (Gene ID 1045) in human. CDX-2 is a transcription factor that plays an important role during embryonic development, where it determines intestinal identity in the presumptive gut endoderm. CDX-2 is also required for maintenance of intestinal identity in the intestinal epithelium throughout adulthood. Mitogen-activated protein kinases (MAPK) are reported to modulate CDX2 transcriptional activity and half-life via phosphorylation. Reduction of CDX2 expression facilitates tumor progression in murine models of colorectal cancer (CRC) and decreased CDX2 expression level in CRC correlates with poor prognosis in human.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Homeobox protein CDX-2 Antibody, clone 7D9.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Homeobox protein CDX-2.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Homeobox protein CDX-2 in human colon and human colorectal cancer tissue.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to human Homeobox protein CDX-2.
EpitopeInternal
Clone7D9.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • CDX2
  • CDX3
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~35/39 kDa observed. Target band often appears as a doublet due to posttranslational modifications (phosphorylations & polyubiquitinations).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human colorectal adenocarcinoma DLD-1 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Homeobox protein CDX-2 in 10 µg of human colorectal adenocarcinoma DLD-1 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
MABE988 04055977182804

Documentation

Anti-Homeobox protein CDX-2 Antibody, clone 7D9.1 SDS

Title

Safety Data Sheet (SDS) 

Anti-Homeobox protein CDX-2 Antibody, clone 7D9.1 Certificates of Analysis

TitleLot Number
Anti-Homeobox protein CDX-2, -Q2589918 Q2589918
Anti-Homeobox protein CDX-2, clone 7D9.1 - 3731604 3731604

Technical Info

Title
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.