Millipore Sigma Vibrant Logo
Attention: We have moved. EMD Millipore products are no longer available for purchase on emdmillipore.com.Learn More

AB9880 Anti-Huntingtin-Interacting Protein (HIP1) Antibody

Anti-Huntingtin-Interacting Protein (HIP1) Antibody detects level of Huntingtin-Interacting Protein (HIP1) & has been published & validated for use in WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases, Synapse & Synaptic Biology Gene Symbol: HIP1, HIP-I, MGC126506, ILWEQ UniProt Number: O00291
View Products on Sigmaaldrich.com
AB9880
100 µL  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RWBRbPurifiedPolyclonal Antibody
Description
Catalogue NumberAB9880
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Huntingtin-Interacting Protein (HIP1) Antibody
Alternate Names
  • HIP1
References
Product Information
FormatPurified
PresentationLiquid
Quality LevelMQ100
Applications
ApplicationAnti-Huntingtin-Interacting Protein (HIP1) Antibody detects level of Huntingtin-Interacting Protein (HIP1) & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Application NotesWestern blot: 1:500-1:1,000 on P2 microsomal fraction from embryonic rat brain.





Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenSynthetic peptide
HostRabbit
SpecificityHuntingtin-interacting protein 1 (HIP1). By Western blot the antibody recognizes a band at ~116 kDa on P2 microsomal fraction from embryonic rat brain.
Species Reactivity
  • Human
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. An alternative splice variant of this gene has been described but its full length sequence has not been determined.
Gene Symbol
  • HIP1
  • HIP-I
  • MGC126506
  • ILWEQ
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O00291 # May play a functional role in the cell filament networks.
SIZE: 1030 amino acids; 115442 Da
SUBUNIT: Binds huntingtin. This interaction is restricted to the brain. Binds to Hippi.
SUBCELLULAR LOCATION: Intracytoplasmic membrane.
TISSUE SPECIFICITY: Ubiquitously expressed with the highest level in brain.
SIMILARITY: SwissProt: O00291 ## Belongs to the SLA2 family. & Contains 1 ENTH (epsin N-terminal homology) domain. & Contains 1 I/LWEQ domain.
MISCELLANEOUS: The affinity of the huntingtin protein-HIP1 interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.
Molecular Weight116 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
AB9880 04053252729522