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MABT908 Anti-Integrin beta-8 Antibody, clone 6B9

This mouse monoclonal Anti-Integrin beta-8 Antibody, clone 6B9, Cat. No. MABT908, is tested for use in Immunohistochemistry (Paraffin) for the detection of Integrin beta-8.

Anti-Integrin beta-8 Antibody, clone 6B9 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Gene Symbol: ITGB8 UniProt Number: P26012
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MABT908
100 µL  
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Overview

Replacement Information

Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HIH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABT908
DescriptionAnti-Integrin beta-8 Antibody, clone 6B9
Alternate Names
  • ITGB8
Background InformationIntegrin beta-8 (UniProt: P26012) is encoded by the ITGB8 gene (Gene ID: 3696) in human. Integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. The integrin receptors are composed of alpha and beta subunits and each subunit crosses the membrane once, with most of the polypeptide residing in the extracellular space, and has two short cytoplasmic domains. Integrin beta-8 is a single-pass type I membrane protein that associates with alpha V chain in a non-covalent manner to make a heterodimer that serves as a receptor for vitronectin, fibrin, and the latency associated peptide (LAP). Integrin beta-8 binding to LAP is reported to promote the proteolytic release of active TGF-beta from LAP. Integrin beta-8 contains a VWFA domain and four cysteine-rich repeats. It is required for vascular morphogenesis in the embryonic brain and yolk sac. Higher expression of integrin beta-8 is observed in placenta, kidney, brain, ovary, uterus, and in several transformed cells. It is transiently expressed in 293 human embryonic kidney cells. Higher expression of ITGB8 is linked to high angiogenic and poorly invasive glioblastoma tumors. Conversely, low expression of ITGB8 correlates with highly invasive, but low angiogenic tumors. Higher expression of integrin beta-8 is observed in placenta, kidney, brain, ovary, uterus, and in several transformed cells. It is transiently expressed in 293 human embryonic kidney cells.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis mouse monoclonal Anti-Integrin beta-8 Antibody, clone 6B9, Cat. No. MABT908, is tested for use in Immunohistochemistry (Paraffin) for the detection of Integrin beta-8.
Key Applications
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Integrin beta-8 in human colon and human placenta tissues.
Biological Information
ImmunogenA truncated recombinant form of human Integrin B8 corresponding to first 682 amino acids.
Clone6B9
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone 6B9 detects human integrin beta-8 subunit.
IsotypeIgG1κ
Species Reactivity
  • Human
Species Reactivity NoteHuman.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • ITGB8
Purification MethodProtein G purified
UniProt Number
Molecular Weight85.63 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in human colon tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Integrin beta-8 in human colon tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
MABT908 04054839197505