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MABF41 Anti-Interleukin-6 (IL-6) Antibody, clone 1G3

Anti-Interleukin-6 (IL-6) Antibody, clone 1G3 is an antibody against Interleukin-6 (IL-6) for use in WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Cytokines & Cytokine Receptors Gene Symbol: IL6, IL-6, CDF, HSF, HGF, BSF2, IFNB2, BSF-2 UniProt Number: P05231
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MABF41
100 µg  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABF41
Replaces04-1095
DescriptionAnti-Interleukin-6 (IL-6) Antibody, clone 1G3
Alternate Names
  • interleukin 6 (interferon, beta 2)
  • IFN-beta-2
  • B-cell stimulatory factor 2
  • interleukin-6
  • Interferon beta-2
  • B cell stimulatory factor-2
  • Hybridoma growth factor
  • B-cell differentiation factor
  • CTL differentiation factor
  • interleukin BSF-2
Background InformationInterleukin-6 (IL-6) is a pro-inflammatory cytokine that seems to be involved in the late stages of CTL generation. Other biological functions also include amplification and the inflammatory response. Combination therapies including IL-6 have been shown to have positive effects on specific malignant tumor types. The accumulation of IL-6 in the CNS is usually detrimental and can contribute to pathology of CNS diseases. IL-6 signaling is negatively regulated by TGF-beta, which down regulates STAT1, STAT3 and ICAM-1 expression. IL-6 expression has been linked to inflammatory bowel disease (IBD) and is also the primary clinical target for IBD. Clinical use of an antibody for the IL-6 receptor (IL-6R) has been promising in treating rheumatoid arthritis, systemic juvenile idiopathic arthritis and Castleman’s disease.
References
Product Information
FormatPurified
Control
  • Human IL-6 recombinant protein
PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Interleukin-6 (IL-6) Antibody, clone 1G3 is an antibody against Interleukin-6 (IL-6) for use in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenHuman IL-6 fused to the soluble domain of the IL-6R.
CloneAB42_51.38C8.1G3
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
IsotypeIgG2bκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a cytokine that functions in inflammation and the maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq].
Gene Symbol
  • IL6
  • IL-6
  • CDF
  • HSF
  • HGF
  • BSF2
  • IFNB2
  • BSF-2
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.

SUBCELLULAR LOCATION: Secreted.

PTM: N- and O-glycosylated.

POLYMORPHISM: Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.

INVOLVEMENT IN DISEASE: Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.

Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.

SEQUENCE SIMILARITIES: Belongs to the IL-6 superfamily.
Molecular Weight~21 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot with human IL-6 recombinant protein.

Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human IL-6 recombinant protein.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
MABF41 04053252422522

Documentation

Anti-Interleukin-6 (IL-6) Antibody, clone 1G3 SDS

Title

Safety Data Sheet (SDS) 

Anti-Interleukin-6 (IL-6) Antibody, clone 1G3 Certificates of Analysis

TitleLot Number
Anti-Interleukin-6 (IL-6), clone 1G3 - 2383996 2383996
Anti-Interleukin-6 (IL-6), clone 1G3 - 1963085 1963085
Anti-Interleukin-6 (IL-6), clone 1G3 - 2224490 2224490
Anti-Interleukin-6 (IL-6), clone 1G3 - 3506600 3506600
Anti-Interleukin-6 (IL-6), clone 1G3 - 3951360 3951360
Anti-Interleukin-6 (IL-6), clone 1G3 - NRG1843224 NRG1843224
Anti-Interleukin-6 (IL-6), clone 1G3 -2606916 2606916
Anti-Interleukin-6 (IL-6), clone 1G3 -2637129 2637129
Anti-Interleukin-6 (IL-6), clone 1G3 -2665819 2665819
Anti-Interleukin-6 (IL-6), clone 1G3 -2887640 2887640
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