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ABS1485 Anti-Kinesin-like protein KIF7

This rabbit polyclonal Anti-Kinesin-like protein KIF7 Antibody, Cat. No. ABS1485 is validated for use in Western Blotting for the detection of Kinesin-like protein KIF7.

Anti-Kinesin-like protein KIF7 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Gene Symbol: KIF7, UNQ340/PRO539 UniProt Number: Q2M1P5
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ABS1485
100 μg  
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Overview

Replacement Information

Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABS1485
DescriptionAnti-Kinesin-like protein KIF7
Alternate Names
  • KIF7
Background InformationKinesin-like protein KIF7 (UniProt: Q2M1P5; also known as KIF7) is encoded by the KIF7 (also known as UNQ340/PRO539) gene (Gene ID: 374654) in human. KIF7 is a member of kinesin-4 family that is essential for hedgehog signaling regulation. It localizes to cilia tips, the site of microtubule plus-ends, where it limits cilia length and controls cilia structure. KIF7 is required for the normal structure of primary cilia and in the absence of KIF7, cilia are long and unstable. KIF7 acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms. It negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator Gli2 in the absence of ligand and positively regulates Shh signaling by preventing the processing of the Gli3 into its repressor form. KIF7 physically interacts with Gli transcription factors and controls their proteolysis and stability. Defects in KIF7 gene can lead to ciliary dysfunction, which result in a broad spectrum of disorders, collectively termed ciliopathies, including the Bardet-Biedl syndrome, a syndrome characterized by severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation, and mental retardation. (Ref.: Cheung. H.O. et al. (2009). Sci. Signal. 2(76):ra29).
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis rabbit polyclonal Anti-Kinesin-like protein KIF7 Antibody, Cat. No. ABS1485 is validated for use in Western Blotting for the detection of Kinesin-like protein KIF7.
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-cojugated linear peptide corresponding to 14 amino acid fragment from the C-terminal region of human Kinesin-like protein KIF7.
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityDetects Kinesin-like protein KIF7 in HEK293 cells by Western blotting.
Species Reactivity
  • Human
Species Reactivity NoteHuman.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • KIF7
  • UNQ340/PRO539
Purification MethodAffinity Purified
UniProt Number
Molecular Weight~160 kDa observed; 150.59 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HEK293 cell lysates.

Western Blotting Analysis: 2 µg/mL of this antibody detected Kinesin-like protein KIF7 in 10 µg of HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
ABS1485 04054839153143