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MABS1290 Anti-LANCL2 Antibody, clone 392

Detect LANCL2 using this mouse monoclonal Anti-LANCL2 Antibody, clone 392, Cat. No. MABS1290. It is used in Immunocytochemistry and Western Blotting.

Anti-LANCL2 Antibody, clone 392 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: LANCL2, GPR69B, TASP UniProt Number: Q9NS86
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MABS1290
100 μg  
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Overview

Replacement Information

Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HICC, WBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABS1290
DescriptionAnti-LANCL2 Antibody, clone 392
Alternate Names
  • Testis-specific adriamycin sensitivity protein
Background InformationLanC-like protein 2 (UniProt: Q9NS86; also known as Testis-specific adriamycin sensitivity protein) is encoded by the LANCL2 (also known as GPR69B, TASP) gene (Gene ID: 55915) in human. LANC2 is a member of the highly conserved and widely distributed lanthionine synthetase component C-like (LANCL) protein family. It is well expressed in brain and testis and is localized to the plasma membrane, juxta-nuclear vesicles, and the nucleus. The N-terminus of LANCL2 differs from the other LANCL proteins by an N-terminal extension of 17 amino acid residues and an insertion of 19 residues. LANCL2 contains 15 cysteine residues, three of which are conserved in all human LANCL proteins and 8 are conserved between LANCL2 and LANCL1. LANCL2 displays about 75% amino acid homology with LANCL1 protein. LANCL2 contains a phosphatidylinositol phosphate (PIP) binding site at the N-terminus and its myristoylation is essential for its membrane association. LANCL2 is essential for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. Exogenous expression LANCL2 in a sarcoma cell line is shown to reduce the expression of ABCB1 (P-glycoprotein 1) and increase cellular sensitivity to adriamycin. (Ref.: Sturla, L et al. (2009). J. Biol. Chem. 284(41):28045-57; Ladlinger, C et al. (2006). Biochim Biophys Acta. 1758(11):1759-67).
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgG1 in PBS with 0.02% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect LANCL2 using this mouse monoclonal Anti-LANCL2 Antibody, clone 392, Cat. No. MABS1290. It is used in Immunocytochemistry and Western Blotting.
Key Applications
  • Immunocytochemistry
  • Western Blotting
Application NotesImmunocytochemistry Analysis: A representative lot detected LANCL2 in Immunocytochemistry applications (Fresia, C., et. al. (2016). Sci Rep. 6:26658).

Western Blotting Analysis: A representative lot detected LANCL2 in Western Blotting applications (Vigliarolo, T., et. al. (2015). J Biol Chem. 290(21):13042-52; Vigliarolo, T., et. al. (2016). Int J Biochem Cell Biol. 75:99-103).
Biological Information
ImmunogenGST-tagged full length human recombinant LANCL2 protein.
Epitopeunknown
Clone392
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone 392 detected LANCL2 overexpressed in HEK293 cells.
IsotypeIgG1κ
Species Reactivity
  • Human
Species Reactivity NoteHuman.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • LANCL2
  • GPR69B
  • TASP
Purification MethodProtein A purified
UniProt Number
Molecular Weight~50 kDa observed; 50.85 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in lysates from HEK293 cells overexpressing LANCL2.

Western Blotting Analysis: 4 µg/mL of this antibody detected LANCL2 in 10 µg of cell lysate from HEK293 cells overexpressing LANCL2.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
MABS1290 04054839167515