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MABN643 Anti-NDUFS3 Antibody, clone 6H7.1

This Anti-NDUFS3 Antibody, clone 6H7.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of NDUFS3.

Anti-NDUFS3 Antibody, clone 6H7.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: NDUFS3 UniProt Number: O75489
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MABN643
100 µg  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RWB, IH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN643
DescriptionAnti-NDUFS3 Antibody, clone 6H7.1
Alternate Names
  • NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
  • Complex I-30kD
  • CI-30kD
  • NADH-ubiquinone oxidoreductase 30 kDa subunit
Background InformationNDUFS3 is the core subunit of the mitochondrial respiratory chain's NADH dehydrogenase complex, also known as Complex I, the complex critical for the production of ATP and NADH electron transfer. In mammals Complex I consists of some 45 different proteins, NDUFS3 is the critical core subunit of the complex. Expressed in all cells and localized in the mitochondria but encoded by a nuclear gene, NDUFS3 plays a critical role in electron transport, our internal cellular respiratory chain, and mitochondrial function. NDUFS3 also is important in disease phenotypes and various cancers. Mutations in NDUFS3 give rise to Leigh syndrome a mitochondrial dysfunctional disease. In cancers, down regulation of NDUFS3 is linked with lowered host survival and increased cancer pathology.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-NDUFS3 Antibody, clone 6H7.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of NDUFS3.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected NDUFS3 in human cerebral cortex, rat hippocampus, and rat cerebellum tissue.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to human NDUFS3.
Clone6H7.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • NDUFS3
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~30 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in THP-1 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected NDUFS3 in 200 µg of THP-1 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
MABN643 04055977052237