Millipore Sigma Vibrant Logo
Attention: We have moved. EMD Millipore products are no longer available for purchase on emdmillipore.com.Learn More

ABN1733 Anti-NTT4/SLC6A17 Antibody

Anti-NTT4 Antibody is an antibody against SLC6A17 for use in Western Blotting, Immunofluorescence.

Anti-NTT4/SLC6A17 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: Slc6a17, Ntt4, Rxt1 UniProt Number: P31662
ABN1733
100 µL  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
RWB, IFRbSerumPolyclonal Antibody
Description
Catalogue NumberABN1733
DescriptionAnti-NTT4/SLC6A17 Antibody
Alternate Names
  • B0AT3
  • Sodium-dependent neutral amino acid transporter SLC6A17
  • Sodium-dependent neurotransmitter transporter NTT4
  • Solute carrier family 6 member 17
Background InformationSodium-dependent neutral amino acid transporter SLC6A17 (UniProt P31662; also known as B0AT3, Sodium-dependent neurotransmitter transporter NTT4, Solute carrier family 6 member 17) is encoded by the Slc6a17 (also known as Ntt4, Rxt1) gene (Gene ID 613226) in rat species. SLC6A17/B0AT3 is a member of the SLC6 family of proteins, many of which function as presynaptic reuptake transporters. SLC6 transporters are calssified as secondary active transporters because they are driven by electrochemical Na+ or H+ gradients. Na+ gradients are maintained over the plasma membrane of all cells, while H+ gradients are maintained over internal membranes such as synaptic vesicles. The SLC6 members are divided based on their substrates into four subgroups termed GABA, monoamine, amino acid, and neutral amino acids (originally called orphans). SLC6A17/B0AT3 acts as a transporter of a broad range of neutral amino acids with affinity for proline, leucine, glycine, alanine, and glutamine. SLC6A17/B0AT3 is found exclusively in axon terminals of most glutamatergic neurons and in a sub-population of GABAergic neurons throughout the central nervous system (CNS). Although yet to be verified, SLC6A17/B0AT3 could play a role in synaptic remodeling, a process important for the long-term action of antidepressant drugs as well as for other CNS functions.
References
Product Information
FormatSerum
PresentationRabbit polyclonal antibody serum with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-NTT4 Antibody is an antibody against SLC6A17 for use in Western Blotting, Immunofluorescence.
Key Applications
  • Western Blotting
  • Immunofluorescence
Application NotesImmunofluorescence Analysis: A 1:2,000 dilution from a representative lot detected SLC6A17 immunoreactivity in adult rat hippocampus tissue sections by fluorescent immunohistochemistry (Courtesy of Dr. Jeffrey D. Erickson, Louisiana State University Health Science Center, New Orleans, LA).
Biological Information
ImmunogenGST-tagged recombinant rat Ntt4/Slc6a17 C-terminal cytoplasmic tail.
EpitopeC-terminal cytoplasmic tail.
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThis polyclonal antiserum targets the C-terminal cytoplasmic tail of rat SLC6A17. Cross-reactivity toward human and murine SLC6A17 is predicted based on high sequence homology.
Species Reactivity
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • Slc6a17
  • Ntt4
  • Rxt1
Purification MethodUnpurified
UniProt Number
Molecular Weight~75 kDa observed. 81.06 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in rat PC12 pheochromocytoma cell lysate.

Western Blotting Analysis: An 1:1,000 dilution of this antibody detected NTT4/SLC6A17 in 10 µg of rat PC12 pheochromocytoma cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
ABN1733 04055977332285