Millipore Sigma Vibrant Logo
Attention: We have moved. EMD Millipore products are no longer available for purchase on emdmillipore.com.Learn More

AB5404 Anti-Neurturin Antibody

View Products on Sigmaaldrich.com
AB5404
50 µL  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RIHCRbSerumPolyclonal Antibody
Description
Catalogue NumberAB5404
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Neurturin Antibody
References
Product Information
FormatSerum
PresentationRabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
Quality LevelMQ100
Applications
ApplicationAnti-Neurturin Antibody detects level of Neurturin & has been published & validated for use in IH.
Key Applications
  • Immunohistochemistry
Application NotesImmunohistochemistry: 1:1,000-1:2,000

Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenRecombinant human Neurturin.
HostRabbit
SpecificityNeurturin. No cross reactivity with GDNF.
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryNeurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease.
Gene Symbol
  • NRTN
  • NTN
  • neurturin
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q99748 # Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
SIZE: 197 amino acids; 22405 Da
SUBUNIT: Homodimer; disulfide-linked.
SUBCELLULAR LOCATION: Secreted.
DISEASE: SwissProt: Q99748 # Defects in NRTN are a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
SIMILARITY: SwissProt: Q99748 ## Belongs to the TGF-beta family. GDNF subfamily.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size50 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
AB5404 04053252272585

Documentation

Anti-Neurturin Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-Neurturin Antibody Certificates of Analysis

TitleLot Number
RABBIT ANTI-NEURTURIN - 3195398 3195398
RABBIT ANTI-NEURTURIN - 3255323 3255323
RABBIT ANTI-NEURTURIN - 3587185 3587185
RABBIT ANTI-NEURTURIN - 3693096 3693096
RABBIT ANTI-NEURTURIN -2681164 2681164
RABBIT ANTI-NEURTURIN -2887225 2887225
RABBIT ANTI-NEURTURIN POLYCLONAL ANTIBODY 2485723
RABBIT ANTI-NEURTURIN POLYCLONAL ANTIBODY 3083068
RABBIT ANTI-NEURTURIN POLYCLONAL ANTIBODY - 2053346 2053346
RABBIT ANTI-NEURTURIN POLYCLONAL ANTIBODY - 2537447 2537447

References

Reference overviewApplicationSpeciesPub Med ID
Long-term preservation of cone photoreceptors and visual acuity in rd10 mutant mice exposed to continuous environmental enrichment.
Barone, I; Novelli, E; Strettoi, E
Molecular vision  20  1545-56  2014

Show Abstract
ImmunohistochemistryMouse25489227 25489227
Environmental enrichment extends photoreceptor survival and visual function in a mouse model of retinitis pigmentosa.
Barone, I; Novelli, E; Piano, I; Gargini, C; Strettoi, E
PloS one  7  e50726  2012

Show Abstract
23209820 23209820
Neurturin, a relative of glial-cell-derived neurotrophic factor
Kotzbauer, P. et al.
Nature, 384:467-470 (1996)  1996

8945474 8945474

Data Sheet

Title
RABBIT ANTI-NEURTURIN POLYCLONAL ANTIBODY