Millipore Sigma Vibrant Logo
Attention: We have moved. EMD Millipore products are no longer available for purchase on emdmillipore.com.Learn More

MABC598 Anti-PACS2 Antibody, clone 9F12.2

This Anti-PACS2 antibody is validated for use in Western Blotting for the detection of PACS2.

Anti-PACS2 Antibody, clone 9F12.2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: PACS2, KIAA0602, PACS1L UniProt Number: Q86VP3
View Products on Sigmaaldrich.com
MABC598
100 µg  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
R, MWBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC598
DescriptionAnti-PACS2 Antibody, clone 9F12.2
Alternate Names
  • Phosphofurin acidic cluster sorting protein 2
  • PACS1-like protein
  • PACS2
Background InformationPhosphofurin acidic cluster sorting protein 2 (PACS2), also known as PACS-2, PACS1-like protein, and encoded by the gene name PACS2/ KIAA0602/ PACS1L, is a amember of the PACS family. PACS2 is a multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. Additionally, PACS2 translocates BIB to mitochondria in response to apoptic inducers, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome C, and the activation of caspase-3 thereby causing cell death. Recent studies have indicated that PACS2 may also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. PACS2 interacts with BID, PKD2, and HIV-1 Nef.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-PACS2 antibody is validated for use in Western Blotting for the detection of PACS2.
Key Applications
  • Western Blotting
Application NotesWestern Blotting Analysis: A 1:500 dilution from a representative lot detected PACS2 in 10 µg of mouse hypothalamus tissue.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to Human PACS2.
Clone9F12.2
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Rat
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • PACS2
  • KIAA0602
  • PACS1L
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~100 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in rat hippocampus tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected PACS2 in 10 µg of rat hippocampus tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
MABC598 04055977122312