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AB939-I Anti-Pancreatic Polypeptide

Anti-Pancreatic Polypeptide Antibody, Cat. No. AB939-I, is a highly specific rabbit polyclonal antibody that targets Pancreatic polypeptide and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-Pancreatic Polypeptide MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: PPY, PNP UniProt Number: P01298
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AB939-I
100 µL  
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Overview

Replacement Information

Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P)RbPurifiedPolyclonal Antibody
Description
Catalogue NumberAB939-I
DescriptionAnti-Pancreatic Polypeptide
Alternate Names
  • Pancreatic hormone
  • PP
  • Obinepitide
Background InformationPancreatic polypeptide (UniProt: P01298; also known as PP, Obinepitide, Pancreatic prohormone) is encoded by the PPY (also known as PNP) gene (Gene ID: 5539) in human. Pancreatic polypeptide is a member of the neuropeptide Y family and is secreted protein that is produced by PP cells in the pancreatic islets of Langerhans. It is synthesized with a signal peptide (aa 1-29), which is subsequently cleaved off. It acts as a regulator of pancreatic and gastrointestinal functions. Two isoforms of pancreatic polypeptide have been described that are generated by alternative splicing. Pancreatic polypeptide release is functionally associated with increased satiety, delayed gastric emptying, inhibition of gallbladder motility, and regulation of energy expenditure. Its deficiency is observed in cases of pancreatic resection and chronic pancreatitis and is associated with significant reduction in PP cell mass and abnormally high hepatic glucose production even in the presence of endogenous insulin. (Ref.: Maxwell, J et al. (2014). Pancreas 43(4); 651-656).
References
Product Information
FormatPurified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Pancreatic Polypeptide Antibody, Cat. No. AB939-I, is a highly specific rabbit polyclonal antibody that targets Pancreatic polypeptide and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesWestern Blotting Analysis: 1:2,000 dilution from a representative lot detected Pancreatic Polypeptide in 10 µg of human pancreas tissue lysate.

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Pancreatic Polypeptide in human pancreas tissue sections.

Immunocytochemistry Analysis (ICC): A 1:500 dilution from a representative lot detected Pancreatic Polypeptide in TGP52 cell line.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to 36 amino acids the internal region of human pancreatic polypeptide.
Epitopecytoplasmic domain
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThis rabbit polyclonal antibody detects both isoforms of human pancreatic polypeptide. It targets an epitope within 36 amino acids from the internal region.
Species Reactivity
  • Human
Species Reactivity NoteHuman. Predicted to react with Rhesus Macaque based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • PPY
  • PNP
Purification MethodAffinity Purified
UniProt Number
Molecular Weight~11 and ~20 kDa observed for isoforms 1 and 2; 10.45 and 18.79 kDa calculated for isoforms 1 and 2. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in PANC-1 cell lysate.

Western Blotting Analysis: 1:2,000 dilution of this antibody detected Pancreatic Polypeptide in 10 µg of PANC-1 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
AB939-I 04054839399756