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MAB874-KC Anti-Papillomavirus, 16, 18 E6 protein, clone C1P5 (1mg) KC

Detect Papillomavirus using this Anti-Papillomavirus Antibody, 16, 18 E6 protein, clone C1P5 validated for use in IH & WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
MAB874-KC
Bulk packaging. Please inquire.  
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Description
Catalogue NumberMAB874-KC
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Papillomavirus, 16, 18 E6 protein, clone C1P5 (1mg) KC
OverviewThis product is intended for use by IVD manufacturers.
Contact customer service for assistance: oem.reagents@emdmillipore.com
Alternate Names
  • Anti-HPV
Background InformationHuman papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.
References
Product Information
FormatPurified
Control
  • Human cervical carcinoma extract
PresentationProtein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
Quality LevelMQ300
Applications
ApplicationDetect Papillomavirus using this Anti-Papillomavirus Antibody, 16, 18 E6 protein, clone C1P5 validated for use in IH & WB.
Key Applications
  • Immunohistochemistry
  • Western Blotting
Application NotesImmunoblotting: Reactive with a 16.5-18 kDa band in reduced westerns of overexpressing cells lines corresponding to HPV E6 protein in cells derived from human cervical carcinoma. {Banks, et al 1987}

Immunohistochemistry: Shows reactivity on formalin fixed tissue. Dilute with buffer pH 7.5-8.0 to desired working volumes. For extensive dilution, protein containing or other stabilizing medium should be used.

Immunopreciptiation: Immunoprecipiates 16.5 kDa band from human cervical carcinoma extracts {Banks, et al, 1987}.

Final working dilutions must be determined by end user.
Biological Information
ImmunogenC1P5 was made against HPV type 18 E6 protein produced in bacteria.
Epitope16, 18 E6 protein
CloneC1P5
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityRecognizes Human papilloma virus type 18 early E6 protein. The antibody cross reacts with E6 protein from HPV type 16.
IsotypeIgG
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Purification MethodProtein A Purfied
Molecular Weight16.5-18 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Minimum order quantity required to qualify. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain for 1 year at 2–8°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Packaging Information
Material SizeBulk packaging. Please inquire.
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
MAB874-KC 04053252519802

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Catalog Number Description
MAB874 Anti-Papillomavirus Antibody, 16, 18 E6 protein, clone C1P5

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Categories

IVD/OEM Materials & Reagents > Bulk & Custom Antibodies > Primary Bulk Antibodies by Target > Viruses by Clinical Condition > STD
Life Science Research > Antibodies and Assays > Primary Antibodies
IVD/OEM Materials & Reagents > Bulk & Custom Antibodies > Primary Bulk Antibodies by Target > Viruses by Clinical Condition > Cancer related Viruses
IVD/OEM Materials & Reagents > Bulk & Custom Antibodies > Primary Bulk Antibodies by Target > Viruses by Family > Papillomavirus