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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABT157 Sigma-AldrichAnti-Parvin alpha Antibody, clone 7E2.1

This Anti-Parvin alpha Antibody, clone 7E2.1 is validated for use in western blotting & IHC (Paraffin) for the detection of Parvin alpha.

Anti-Parvin alpha Antibody, clone 7E2.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Research Category: Cell Structure Research Sub-Category: Cytoskeleton Gene Symbol: PARVA, MXRA2 UniProt Number: Q9NVD7

Replacement Information

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, IH(P)	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABT157
Description	Anti-Parvin alpha Antibody, clone 7E2.1
Alternate Names	Alpha-parvin α-Parvin a-Parvin topaxin CH-ILKBP Calponin-like integrin-linked kinase-binding protein Matrix-remodeling-associated protein 2
Background Information	The protein named α-Parvin or Parvin, or Actopaxin, or Calponin-like integrin-linked kinase-binding protein (CH-ILKBP), or Matrix-remodeling-associated protein 2 (MXRA2), and encoded by the gene PARVA/MXRA2, is a critical adhesion coupling protein involved in many systems including sarcomere organization, smooth muscle contraction, cardiovascular development, angiogenesis, actin cytoskeleton organization and the establishment of cell polarity, adhesion, spreading and migration. α-Parvin is required for the adhesion of smooth muscle cell to endothelial cells during blood vessel development and for the formation of lamellipodia and ciliogenesis. α-Parvin is localized to the cell junction and focal adhesions. The protein is peripheral membrane protein located on the cytoplasmic side of the cell membranes and interacts with the cytoskeleton in the cytoplasm. In muscle cells it is associated with the Z line of the sarcomere. α-Parvin is expressed many tissues including muscle, kidney and liver.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	This Anti-Parvin alpha Antibody, clone 7E2.1 is validated for use in western blotting & IHC (Paraffin) for the detection of Parvin alpha.
Key Applications	Western Blotting Immunohistochemistry (Paraffin)
Application Notes	Immunohistochemistry Analysis: A 1:2,000 dilution and a 1:50 dilution from a representative lot detected Parvin alpha in human kidney and skeletal muscle tissues, respectively.

Biological Information
Immunogen	GST-tagged recombinant protein corresponding to human Parvin.
Clone	7E2.1
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Isotype	IgG1κ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_060692
Gene Symbol	PARVA MXRA2
Purification Method	Protein G Purified
UniProt Number	Q9NVD7
Molecular Weight	~42 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in human heart tissue. Western Blotting Analysis: 0.2 µg/mL of this antibody detected Parvin alpha in 200 µg of human heart tissue.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalog Number	GTIN
MABT157	04053252939815

Title	Lot Number
Anti-Parvin alpha, clone 7E2.1 - Q2343941	Q2343941
Anti-Parvin alpha, clone 7E2.1 - 3523226	3523226

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