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ABN1011 Anti-Peroxiredoxin-2 Antibody

Anti-Peroxiredoxin-2 antibody is an antibody against Peroxiredoxin-2 for use in western blotting & ICC.

Anti-Peroxiredoxin-2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: Prdx2, Tdpx1, Tpx UniProt Number: Q61171
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ABN1011
100 µL  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, H, RWB, ICCRbSerumPolyclonal Antibody
Description
Catalogue NumberABN1011
DescriptionAnti-Peroxiredoxin-2 Antibody
Alternate Names
  • Peroxiredoxin-2
  • Thiol-specific antioxidant protein
  • TSA
  • Thioredoxin peroxidase 1
  • Thioredoxin-dependent peroxide reductase 1
Background InformationThe protein called Peroxiredoxin-2, or in older literature Thiol-specific antioxidant protein, TSA, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1, Natural killer cell-enhancing factor B, PRP, or NKEF-B and encoded by the human gene PRDX2/NKEFB/TDPX1 plays a role in controlling the oxidation state of the cell by reducing peroxides via the Thioredoxin system. Peroxides are produced during normal metabolism and if not reduced, their built up can lead to oxidative stress and cell death. Interestingly Peroxirdoxin-2 can be inactivated itself by oxidative stress on Cys-51 thus its levels are tightly controlled. Peroxiredoxin-2 is particularly important in neurons where it acts as an anti-apoptotic factor but the protein is widely expressed and localizes to the cytoplasm in most cells. Because Peroxiredoxin-2 mediates H2O2 signaling it is considered an anti-aging and anti-cancer protein, but surprisingly recent research in yeast indicates that Peroxiredoxin-2 potentiates H202 levels and signaling by specifically inhibiting other Thioredoxin enzymes via their oxidation. Thus Peroxiredoxin-2 can both inhibit and promote peroxide metabolism depending upon the cellular microenvironment and cell systems being studied.
References
Product Information
FormatSerum
PresentationRabbit polyclonal serum without preservatives.
Quality LevelMQ100
Applications
ApplicationAnti-Peroxiredoxin-2 antibody is an antibody against Peroxiredoxin-2 for use in western blotting & ICC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesWestern Blotting Analysis: A 1:1,000 dilution from a representative lot detected Peroxiredoxin-2 in 10 µg of human brain and rat hippocampus tissue lysate.

Immunocytochemistry Analysis: A representative lot detected Peroxiredoxin-2 in COS cells (Prof. Mustapha Oulad, IGBMC, France.).
Biological Information
ImmunogenOvalbumin-conjugated linear peptide corresponding to the C-terminus of mouse Peroxiredoxin-2.
EpitopeC-terminus
HostRabbit
Species Reactivity
  • Mouse
  • Human
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • Prdx2
  • Tdpx1
  • Tpx
Purification MethodUnpurified
UniProt Number
Molecular Weight~22 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Peroxiredoxin-2 in 10 µg of mouse brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
ABN1011 04053252970078