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ABN304 Anti-Precerebellin Antibody

This Precerebellin antibody is validated for use in WB & IHC for the detection of the Precerebellin protein.

Anti-Precerebellin Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: CBLN1 UniProt Number: P23435
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ABN304
100 µg  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN304
DescriptionAnti-Precerebellin Antibody
Alternate Names
  • Cerebellin precursor
  • Cerebellin
  • CER
  • Precerebellin
Background InformationPrecerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q. Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells in cartwheel neurons of the dorsal cochlear nucleus. Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin possess functions other than those already stated.
References
Product Information
FormatAffinity Purified
Control
  • Mouse cerebellum tissue lysate
PresentationPurified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Precerebellin antibody is validated for use in WB & IHC for the detection of the Precerebellin protein.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Precerebellin in human cerebellum tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human Precerebellin.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
  • Mouse
Antibody TypePolyclonal Antibody
Gene Symbol
  • CBLN1
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~35 kDa observed. The calculated molecular weight is 22 kDa, however, the full length Precerebellin has been shown as a ~35 kDa band. (Bao, D., et al. (2005). Journal of Neurochemistry. 95:618-629.) An uncharacterized band may appear at ~50 kDa in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in mouse cerebellum lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Precerebellin in 10 µg/mL of mouse cerebellum tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
ABN304 04053252830969