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ABN325 Anti-SAPAP3 Antibody

This SAPAP3 antibody is validated for use in WB & IHC for the detection of the SAPAP3 protein.

Anti-SAPAP3 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: DLGAP1 UniProt Number: O95886
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ABN325
100 µg  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, R, HWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN325
DescriptionAnti-SAPAP3 Antibody
Alternate Names
  • SAP90
  • PSD-95-associated protein 3
  • Disks large-associated protein 3
  • DLGAP3
Background InformationSAP90/PSD-95-associated protein 3 (SAPAP3, also known as DLGAP3) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP3 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). Both SAPAP3 protein and mRNA are targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are detected mainly in cell bodies. Recent experiments have suggested that SAPAP3 may be involved in obsessive-compulsive disorder (OCD), as mice lacking SAPAP3 exhibited OCD-like symptoms which could be relieved by lentiviral-mediated selective expression of SAPAP3 in the striatum of SAPAP3-mutant mice. At least two isoforms are known to exist.
References
Product Information
FormatAffinity Purified
Control
  • Rat brain tissue lysate
PresentationPurified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis SAPAP3 antibody is validated for use in WB & IHC for the detection of the SAPAP3 protein.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected SAPAP3 in mouse midbrain tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human SAPAP3.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes isoforms SAPAP3α and SAPAP3β.
Species Reactivity
  • Mouse
  • Rat
  • Human
Species Reactivity NoteDemonstrated to react with Mouse and Rat. Predicted to react with Human based on immunogen design.
Antibody TypePolyclonal Antibody
Gene Symbol
  • DLGAP1
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~110/130 kDa observed.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in rat brain tissue lysate.

Western Blot Analysis: 2 µg/mL of this antibody detected SAPAP3 in 15 µg/mL of rat brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
ABN325 04053252831072