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MABC277 Anti-SOX9 Antibody, clone 10E4.1

Anti-SOX9 Antibody, clone 10E4.1 is an antibody against SOX9 for use in Immunohistochemistry (Paraffin), Immunoprecipitation.

Anti-SOX9 Antibody, clone 10E4.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Transcription Factors Gene Symbol: SOX9, CMD1, CMPD1, SRA1 UniProt Number: P48436
MABC277
100 μg  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RIH(P), IPMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC277
DescriptionAnti-SOX9 Antibody, clone 10E4.1
Alternate Names
  • Transcription factor SOX-9
  • Sex-determining region Y-box 9 protein
  • SRY-related HMG-box gene 9
Background InformationTranscription factor SOX-9 (UniProt P48436; also known as Sex-determining region Y-box 9 protein, SRY-related HMG-box gene 9) is encoded by the SOX9 (also known as CMD1, CMPD1, SRA1) gene (Gene ID 6662) in human. Sox family of genes are related to the mammalian sex determining gene SRY. These genes contain sequences encoding for the HMG-box domains that mediate sequence-specific DNA binding. SOX genes encode transcriptional regulators involved in cell fate decision during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at at least 40 genomic loci and at least 30 Sox genes have been identified. SOX-9 is a key regulator of developmental processes, including male sex determination, chondrogenesis, neurogenesis, and neural crest development. SOX-9 up-regulation is reported in cancers of various origins, including breast, colon, prostate, and lung, where its expression correlates with malignancy and patient survival. Cellular SOX9 mRNA is shown to be targeted and negatively regulated by miR-32, and the cellular miR-32 level is reported to be significantly lower in non-small cell lung cancer (NSCLC) compared with noncancerous lung tissues.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-SOX9 Antibody, clone 10E4.1 is an antibody against SOX9 for use in Immunohistochemistry (Paraffin), Immunoprecipitation.
Key Applications
  • Immunohistochemistry (Paraffin)
  • Immunoprecipitation
Application NotesImmunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated SOX9 from 500 µg of human chondrocyte lysate.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to a sequence from the N-terminal region of human SOX9.
EpitopeN-terminal region.
Clone10E4.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone 10E4.1 recognizes an epitope in the N-terminal region of SOX-9.
IsotypeIgG1κ
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • SOX9
  • CMD1
  • CMPD1
  • SRA1
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~65 kDa observed. 56.14 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in rat testis tissue.

Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected SOX9 in rat testis tissue sections.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
MABC277 04055977332247