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06-913-I Anti-Sin3A Antibody

Anti-Sin3A Antibody is an antibody against Sin3A Antibody for use in Western Blotting and Immunocytochemistry.

Anti-Sin3A Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: Sin3a, Kiaa4126 UniProt Number: Q60520
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06-913-I
100 μg  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, HWB, ICCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue Number06-913-I
Replaces06-913
DescriptionAnti-Sin3A Antibody
Alternate Names
  • Paired amphipathic helix protein Sin3a
  • Histone deacetylase complex subunit Sin3a
  • Transcriptional corepressor Sin3a
  • Sin3A
Background InformationPaired amphipathic helix protein Sin3a (UniProt Q60520; also known as Histone deacetylase complex subunit Sin3a, mSin3a, Transcriptional co-repressor Sin3a) is encoded by the Sin3A (also known as mSin3A, AW553200, Kiaa4126, mKIAA4126) gene (Gene ID 8819) in murine species. The transcription regulator Sin3a is a scaffold protein that interacts with various proteins to form specialized complexes that mediate different biological processes, including chromatin modification, embryonic development, DNA repair, mitochondrial metabolism, and gene transcription. SIN3a harbors four paired α-helices (PAH), a histone interaction domain, and a highly conserved region. The histone interaction domain mediates HDACs binding, whereas the highly conserved region interacts with proteins necessary for repression, such as the nuclear receptor hormone co-repressor Alien. The four PAHs represent the main interacting domains of SIN3a and mediate the interactions with a wide variety of DNA-binding transcription factors. Members of the Mad family of repressor proteins, for example, specifically interact with the PAH2 through their Sin3 interacting domain (SID). Although widely studied for its involvement in transcriptional repression, Sin3a is shown to be essential for aryl hydrocarbon receptor-mediated induction of gene transcription.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Sin3A Antibody is an antibody against Sin3A Antibody for use in Western Blotting and Immunocytochemistry.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesImmunocytochemistry Analysis: 4.0 µg/mL from a representative lot detected Sin3A in HeLa, A431, HUVEC, and NIH/3T3 cells.
Biological Information
ImmunogenKLH-conjugated peptide (KRRLDDQESPVYAAQQRR-C) corresponding to amino acids 2-19 of mouse Sin3A.
EpitopeN-terminus
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Mouse
  • Human
Species Reactivity NoteMouse, Human. Predicted to react with Rat, Rhesus Macaque based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • Sin3a
  • Kiaa4126
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~160 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HeLa nuclear extract.

Western Blotting Analysis: 0.05 µg/mL of this antibody detected Sin3A in 10 µg of HeLa nuclear extract.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
06-913-I 04055977294897