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ABN2245-25UG Anti-Somatostatin-28

Anti-Somatostatin-28, Cat. No. ABN2245, is a rabbit polyclonal antibody that detects Somatostain and is tested for use in Immunohistochemistry (Paraffin).

ABN2245-25UG
25 μg  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue NumberABN2245-25UG
DescriptionAnti-Somatostatin-28
Alternate Names
  • Growth hormone release-inhibiting factor
Background InformationSomatostatin (UniProt: P61278; also known as Growth hormone release-inhibiting factor) is encoded by the SST gene (Gene ID: 6750) in human. Somatostatin, a tetradecapeptide, displays highest expression in the islets of Langerhans and in the brain. It is synthesized with a signal peptide (aa 1-24), which is subsequently cleaved off and the remaining chain can cleave into three chains: Neuronostatin (aa 31-43), Somatostatin-28 (aa 89-116), and Somatostatin-14 (aa 103-116). Somatostatin-28 is mainly produced by the intestinal enteroendocrine cells and somatostatin-14 is the predominant form present in the brain. Neuronostatin is believed to enhance low-glucose-induced glucagon release by pancreatic alpha cells. Somatostatin is shown to Inhibit the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. In the intestine it exerts inhibitory effects on various gastrointestinal functions, including gastric acid secretion, gastric emptying, intestinal motility, and release of various gastrointestinal hormones. Somatostatin actions are mediated through five distinct receptor subtypes known as SST1-5 that are G-protein coupled receptors. SST2 and 5 are shown to be the main mediators of the gastrointestinal effects of somatostatin.
References
Product Information
FormatPurified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
ApplicationAnti-Somatostatin-28, Cat. No. ABN2245, is a rabbit polyclonal antibody that detects Somatostain and is tested for use in Immunohistochemistry (Paraffin).
Key Applications
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry (Paraffin) Analysis: A 1:250 dilution from a representative lot detected Somatostatin-28 in human cerebral cortex tissue sections.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to 17 amino acids from the C-terminal region of human Somatostatin that encompasses somatostatin-28 peptide region.
EpitopeC-terminus
Concentration1.0 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
HostRabbit
SpecificityThis rabbit polyclonal antibody detects Somatostatin. It targets an epitope within 17 amino acids from the C-terminal region of Somatostain-28.
IsotypeIgG
Species Reactivity
  • Human
Species Reactivity NoteHuman. Predicted to react with Sheep, Mouse, Bovine based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • SST
Purification MethodAffinity Purified
UniProt Number
Molecular Weight12.74 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in human pancreas tissue sections.

Immunohistochemistry (Paraffin) Analysis: A 1:1,000 dilution of this antibody detected Somatostatin-28 in human pancreas tissue sections.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size25 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
ABN2245-25UG 04061841990130