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AB15562-50UL Anti-Transient Receptor Potential Channel 7 Antibody

Anti-Transient Receptor Potential Channel 7 Antibody is an antibody against Transient Receptor Potential Channel 7 for use in IC & WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: TRPM7, TRP-PLIK, LTRPC7, LTrpC7, FLJ20117, CHAK, FLJ25718, CHAK1, EC 2.7.11.1 UniProt Number: Q96QT4
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AB15562-50UL
50 µL  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, RICC, WBRbPurifiedPolyclonal Antibody
Description
Catalogue NumberAB15562-50UL
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Transient Receptor Potential Channel 7 Antibody
Alternate Names
  • TRPM7
  • LTRPC7
  • Channel-kinase 1
References
Product Information
FormatPurified
Control
  • Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
PresentationLyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
Quality LevelMQ100
Applications
ApplicationAnti-Transient Receptor Potential Channel 7 Antibody is an antibody against Transient Receptor Potential Channel 7 for use in IC & WB.
Key Applications
  • Immunocytochemistry
  • Western Blotting
Application NotesWestern blot: 1:200-1:500 using ECL on mouse brain lysate and GH3 cell line (rat pituitary tumor) lysate.
Immunocytochemistry: 1:200 using GH3 cell line (rat pituitary tumor).
Dilutions should be made using a carrier protein such as BSA (1-3%).
Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenPurified peptide from the C-terminus of human TRPM7 (Accession number Q96QT4).
HostRabbit
SpecificityRecognizes Transient Receptor Potential Channel 7 (TRPM7, LTRPC7, Channel-kinase 1).
Species Reactivity
  • Mouse
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryTRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM]
Gene Symbol
  • TRPM7
  • TRP-PLIK
  • LTRPC7
  • LTrpC7
  • FLJ20117
  • CHAK
  • FLJ25718
  • CHAK1
  • EC 2.7.11.1
Purification MethodImmunoAffinity Purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q96QT4 # Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
SIZE: 1865 amino acids; 212697 Da
SUBUNIT: Homodimer (By similarity). Forms heterodimers with TRPM6.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).
PTM: Autophosphorylated (By similarity).
DISEASE: SwissProt: Q96QT4 # Defects in TRPM7 influences susceptibility to amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 [MIM:105500]; also called amyotrophic lateral sclerosis- parkinsonism/dementia complex of Guam or Guam disease. Amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 is a neurodengenerative disorder with unusually high incidence among the Chamorro people of the Western Pacific Islands of Guam. Both amyotrophic lateral sclerosis and parkinsonism-dementia are chronic, progressive, and uniformly fatal disorders in this population. Both diseases are known to occur in the same kindred, the same sibship, and even the same individual.
SIMILARITY: SwissProt: Q96QT4 ## In the N-terminal section; belongs to the transient receptor family. LTrpC subfamily. & Contains 1 alpha-type protein kinase domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size50 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
AB15562-50UL 04053252404252

Documentation

Anti-Transient Receptor Potential Channel 7 Antibody Certificates of Analysis

TitleLot Number
RABBIT ANTI-TRANSIENT RECEPTOR POTENTIAL CHANNEL 7 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2454979 2454979
RABBIT ANTI-TRANSIENT RECEPTOR POTENTIAL CHANNEL 7 - 3148517 3148517
RABBIT ANTI-TRANSIENT RECEPTOR POTENTIAL CHANNEL 7 - 3497284 3497284
RABBIT ANTI-TRANSIENT RECEPTOR POTENTIAL CHANNEL 7 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2274235 2274235

Data Sheet

Title
RABBIT ANTI-TRANSIENT RECEPTOR POTENTIAL CHANNEL 7 AFFINITY PURIFIED POLYCLONAL ANTIBODY